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Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise

Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05921864
Acronym
PENTHERE
Enrollment
11
Registered
2023-06-27
Start date
2023-06-19
Completion date
2023-07-22
Last updated
2023-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heat, Heat Stress

Keywords

ultra-endurance

Brief summary

Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies. Faced with the challenges of global warming, this issue is becoming increasingly important in the practice of sport. While hyperthermia is known to impair endurance performance, the underlying thermophysiological responses and regulatory mechanisms during prolonged exercise remain poorly understood. The effects of hyperthermia on mental performance raise questions about the degradation of interoceptive capacities and the deleterious impact on behavioral regulation, an important component of thermal risk management in ultra-endurance exercise. What's more, despite the muscular and hydromineral consequences (rhabdomyolysis, renal failure, dehydration) of prolonged exercise, few data are available on recovery kinetics. A better understanding of the factors conditioning recovery quality could help limit the deleterious consequences of ultra-endurance exercise.

Interventions

OTHERPassive heat exposure

Participants will be exposed to heat in a chamber.

OTHERActive heat exposure

Participants will participate to a 6-hour run.

Sponsors

Direction Centrale du Service de Santé des Armées
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 37 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy individuals * BMI between 18 and 25 kg/m2 * Weight ≥ 51 kg * Minimum training volume 6 days/7, aerobic * Participation in a running competition ≥ 6hours * Having given informed consent

Exclusion criteria

* Presence or history of medical pathology * Presence of significant deviation from normal electrocardiogram values * History of heat stroke * Known intolerance to heat * Inability to swallow a capsule or refusal of rectal probe * Alcohol consumption exceeding the equivalent of 3 glasses of wine per week * Consumption of narcotics * Smoking \> 0.5 pack of cigarettes per day * On usual medication * Pregnant or breast-feeding women * Protected adult, under legal protection, guardianship or curatorship, or unable to give personal written consent

Design outcomes

Primary

MeasureTime frameDescription
Degree of correlation between core temperature measured at the end of passive heat exposure and that measured at the end of active heat exposureThrough study completion (1 month)Core temperature will be measured in every participants at the end of passive heat exposure and at the end of active heat exposure. A correlation analysis will be performed on these measurements.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026