Morality, Sepsis, Septic Shock
Conditions
Brief summary
The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.
Detailed description
Several indicators are being used to predict the prognosis of sepsis. Commonly used prognostic indicators include Acute Physiological and chronic health evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Mortality in Emergency Department Score (MEDS), New York Sepsis severity score. Red cell distribution Width and lactate albumin ratio are being investigated for there prognostic value in septic patients.
Interventions
DIAGNOSTIC_TESTRed cell distribution width
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
DIAGNOSTIC_TESTlactate albumin ratio measurement
Blood will be drawn from the peripheral vein, arterial or a central catheter. This procedure will be done at diagnosis, 3 ,7, 14 and 21 days of sepsis
Sponsors
Tanta University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Age from 18 to 60 years old. 2. Clinical criteria of sepsis 3. Or clinical criteria of septic shock including sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure \> 65 mmHg and having a serum lactate level \> 2 mmol/L despite adequate volume resuscitation.
Exclusion criteria
1. No informed consent. 2. Patient with incomplete information and data. 3. The patient who received blood transfusion within 90 days before emergency admission. 4. The patients who are known to have long-term conditions causing anemia like sickle cell anemia, thalassemia, iron deficiency anemia. 5. Malignancy and chemotherapy during the previous 90 days. 6. Patients with either hepatic dysfunction, renal failure, having any disease in which albumin should be supplemented as liver cirrhosis with ascites, nephrotic syndrome and burns.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The prediction of mortality | 28 days | The diagnostic accuracy for prediction of 28th day mortality by Red cell distribution Width and lactate albumin ratio. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of intensive care stay | 28 days or till discharge from intensive care. | Length of intensive care stay from admission till discharge either to the ward or mortality. |
| Extent of organ dysfunctions in patients with severe sepsis and septic shock | 28 days | Organ dysfunction can be confirmed by acute change in sepsis-related organ failure assessment (SOFA). |
Countries
Egypt
Contacts
Primary ContactShimaa S Awd, MBBCh
Outcome results
None listed