Heat Stroke
Conditions
Keywords
heat stroke, normal saline, acute kidney injury, mortality
Brief summary
The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke. Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead. Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.
Interventions
DRUGNormal Saline infusion and Ringer lactate infusion
The heat stroke patients will be infused with different chlorine concentrations fluid during the emergency department.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Yiwu Central Hospital
Jinhua People's Hospital
Jinhua Municipal Central Hospital
Dongyang People's Hospital
Lanxi People's Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years * diagnosed as heat stroke * Informed consent from patients or family members.
Exclusion criteria
* need immediate cardiopulmonary resuscitation * transferred from another hospital * with original end-stage renal disease or dialysis * with severe organ damage * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury | up to 90 days | Acute kidney injury was defined as increase in serum creatinine by 50% within 7 days, or increase in serum creatinine by 0.3 mg/dl (26.5μmol/l) within 2 days, or oliguria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Continuous renal replacement therapy | up to 90 days | number of participants need continuous renal replacement therapy |
| length of ICU stay | up to 90 days | The length patient stay in ICU |
| in-hospital mortality | up to 90 days | number of participants dead in hospital |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORLan Chen, PHD
Second Affiliated Hospital, School of Medicine, Zhejiang University
Outcome results
None listed