Healthy
Conditions
Keywords
Social exclusion, Social separation, Oxytocin, Arginine Vasopressin, fMRI
Brief summary
Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.
Detailed description
A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).
Interventions
DRUGIntranasal Oxytocin
Administer oxytocin (24 IU) intranasally, 6 individual 0.1 ml puffs (4 IU/0. 1ml), three puffs per nostril one every 30 seconds.
DRUGIntranasal Arginine Vasopressin
Administer arginine vasopressin (20 IU) intranasally, 6 individual 0.1 ml puffs (3.33 IU/0. 1ml), three puffs per nostril one every 30 seconds.
DRUGIntranasal placebo
Administer placebo intranasally, 6 individual 0.1 ml puffs, three puffs per nostril one every 30 seconds.
Sponsors
University of Electronic Science and Technology of China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Randomized placebo-controlled double-blind between-subject design
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy subjects; 2. Without any past or present psychiatric or neurological disorders; 3. Without any current psychotherapeutic medication.
Exclusion criteria
1. With any past or present psychiatric or neurological disorders; 2. With any current psychotherapeutic medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks | 45 minutes after treatment administration | Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations |
| Behavioral index: behavioral ratings of social exclusion and social separation tasks | Immediately after fMRI scanning | Comparions between social exclusion and social separation in pain ratings |
Countries
China
Contacts
Primary ContactKeith M Kendrick, Dr
Backup ContactWeihua Zhao, Dr
Outcome results
None listed