Acute Kidney Injury, Cardiopulmonary Bypass, Osmolality Disturbance
Conditions
Keywords
Cardiopulmonary Bypass, Priming Solution, Plasma Osmolality, Acute Kidney Injury
Brief summary
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
Detailed description
Two-hundred cardiac surgical patients were randomised into two groups based on the osmolality level of the prime solution used for cardiopulmonary bypass. The high osmolality group (966 mOsm) received a prime solution containing Ringer-Acetate 1000 ml + Mannitol 400 ml (60 g) + Sodium-Chloride 40 ml (160 mmol) and Heparin 2 ml (10 000 IU), while the reference group with normal osmolality (388 mOsm) received a prime solution containing Ringer-Acetate 1400 ml and Heparin 2 ml (10 000 IU).
Interventions
DRUGHighOsmo
This group received a priming solution with high osmolality
Sponsors
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
Priming of the heart-lung machine performed by a staff member not affiliated to the study protocol.
Intervention model description
Randomisation into two groups based on the osmolality level in the priming solution used for cardiopulmonary bypass.
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient eligible for routine cardiac surgical procedures requiring cardiopulmonary bypass.
Exclusion criteria
* Patients requiring acute surgical intervention within 24 h or profound hypothermia during surgery were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Acute Kidney Injury | Three days | Defined according to the KDIGO definition |
Countries
Sweden
Outcome results
None listed