Intracranial Sacciform Aneurysm
Conditions
Keywords
Intracranial aneurysm, intestinal microbiota, risk factor, ruptured
Brief summary
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation. The objective of this study is to describe microbiota with taxonomic and metabolomic analysis. A comparison between ruptured and unruptured intracranial aneurysm will be performed. The study hypothesis is that microbiota is different between ruptured and unruptured patient.
Interventions
BIOLOGICALanalysis of foecal microbiota
An analysis of foecal microbiota including taxonomic and metabolomic analysis will be performed and compared between ruptured and unruptured patient. confundens factors as diet, obesity for microbiota and as smoking, hypertension, size for aneurysm ruptured will be sampled and independence will be analyzed.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group
Exclusion criteria
* Transient modification of microbiota: Antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like Crohn), BMI for more than 30, Very restrictive diet (like vegan * Specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, Type 1 neurofibromatosis, Rendu-Osler, MArfan * Participation to a study with the objective of microbiota modification
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Taxonomic faecal microbiota description | The faecal samples will be taken at 3 days+/-2 after the ruptured and during the arteriography for the unruptured group within 3 months after inclusion | The results of the taxonomic analysis of fecal samples will be described in the two groups. Interesting parameter will be selected for further analysis |
Contacts
Primary ContactDumot Chloé, Dr PhD
Outcome results
None listed