Comorbid Painful TMD Among Trigeminal Neuralgia

Comorbid Painful Temporomandibular Disorder Among Trigeminal Neuralgia Patients

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05914558

Acronym

TNTMD

Enrollment

Registered

2023-06-22

Start date

2022-08-01

Completion date

2026-08-30

Last updated

2025-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myofascial Pain, Temporomandibular Disorder, Trigeminal Neuralgia, Trigeminal Neuropathy

Brief summary

An observational study following up with trigeminal neuralgia patients to understand their comorbid facial pain condition, specifically temporomandibular disorder.

Detailed description

This multi-center prospective observational cohort study aims to investigate the prevalence of comorbid Temporomandibular disorders (TMD) among trigeminal neuralgia (TN) patients. Trigeminal neuralgia patients with active TN status from three clinical sites (University of Minnesota, School of Dentistry, Orofacial Pain Clinic; Mhealth Fairview, Clinical Surgical Center, Neurosurgery Clinic; John Hopkins University, Anesthesiology, and Critical Care Clinic) could enroll in this study voluntary. All the patients will be evaluated by a provider using standard clinical assessment for TN and TMD, along with validated RedCap questionnaires for TN and TMD diagnosis, and be followed up every six months for 1-2 years.

Interventions

DIAGNOSTIC_TESTClinical appointment

One clinical interview and examination to confirm the diagnosis of trigeminal neuralgia and temporomandibular disorder.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients visited the three clinical sites for facial pain * Patients diagnosed with trigeminal neuralgia * Has active pain symptoms in the past 30 days

Exclusion criteria

* Non-English speakers * Patients with psychiatric disorders that might alter pain perception * Adults lack the capacity to provide informed consent. * Persons under the age of 18. * All vulnerable populations.

Design outcomes

Primary

Measure	Time frame	Description
Prevalence	2 years	Prevalence of comorbid painful TMD among TN patient

Secondary

Measure	Time frame	Description
Diagnostic questionnaire	2 years	The sensitivity, specificity of the diagnostic questionnaire for TN and TMD

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026