Alcohol Use Disorder
Conditions
Brief summary
Addressing cognitive deficits in alcohol use disorder (AUD) supports recovery. Impaired metacognitive functioning in AUD causes compromised recognition of the interoceptive state leading to the maintenance of alcohol abuse despite negative consequences. By promoting greater self-awareness and self-regulation, neurofeedback training is of high relevance in metacognition remediation to support abstinence. The main objective of the present study is to validate neurofeedback as a complementary clinical tool to overcome metacognitive deficits that represent a significant factor in the maintenance of harmful consumption behavior and relapse phenomena in AUD.
Interventions
DEVICENeurofeedback active
Neurofeedback uses real-time displays of brain activity to teach self regulation of brain function. People can learn to control their own brain activity through operant conditioning, where they receive feedback on their brainwaves and learn to modify them to achieve a desired state. Active neurofeedback group aims at enhancing the sensorimotor rhythm (12-15 Hz).
DEVICENeurofeedback placebo
Neurofeedback uses real-time displays of brain activity to teach self regulation of brain function. People can learn to control their own brain activity through operant conditioning, where they receive feedback on their brainwaves and learn to modify them to achieve a desired state. Placebo feedback group (PFT) : patients enhance random frequency bands
Sponsors
Brugmann University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged between 18 and 65 years old undergoing a 3- to 4-week detoxification treatment program at the Alcohol Unit of CHU Brugmann hospital (Brussels, BELGIUM), who have been diagnosed with severe AUD (alcohol use disorder) according to the DSM-V-TR.
Exclusion criteria
* history of neurological disorders * other serious medical conditions * neuroleptic treatment are excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Event related potential | Baseline T0 | Error related negativity (ERN) measurement |
| Metacognition questionnaire-30 (MCQ-30) | Baseline T0 | Metacognitive assessment by means of a questionnaire. Scores from 6 to 24, with higher scores meaning worse outcomes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Commission error rate | Baseline T0 | Behavior assessment |
| Reaction times | Baseline T0 | Behavior assessment |
| Abstinence | Immediately after the last neurofeedback training session T1 | Number of days of abstinence |
Countries
Belgium
Contacts
Primary ContactSalvatore Campanella
Backup ContactClémence Dousset
Outcome results
None listed