Acute Ischemic Stroke, Mechanical Thrombectomy
Conditions
Brief summary
This project investigates the impact of statins on cerebral vascular wall damage after mechanical thrombectomy. The investigators will undertake a multi-center, prospective, parallel-controlled, open-label, superiority randomized controlled study based on past research on intense lipid-lowering intervention trials. Patients undergoing post-thrombectomy will be divided into two groups: the test group and the control group. After surgery, the test group will be given a high dose of atorvastatin (80mg/day), followed by a standard dose (20mg/day). The control group will continue to receive the standard dose of atorvastatin (20mg/day). The investigators will compare the high-resolution vascular wall MRI characteristics (vascular wall enhancement, lumen stenosis rate, and so on) within 3-5 days of the operation, as well as the composite incidence of ischemic stroke, transient ischemic attack, intracranial hemorrhage 1 month postoperatively, and the modified Rankin Score at 90 days.
Interventions
DRUGAtorvastatin 80mg
The test group will undergo high-dose atorvastatin treatment (80mg/day) for the first 3 days after the procedure, transitioning to a standard dose (20mg/day) of atorvastatin thereafter.
DRUGAtorvastatin 20mg
The control group will receive a consistent standard dose (20mg/day) of atorvastatin.
Sponsors
Zhongda Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
Single (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of acute ischemic stroke; 2. With anterior circulation acute stroke who meet and receive emergency endovascular treatment; 3. CTA or DSA confirms anterior circulation intracranial arterial lesions, including MT of intracranial arteries (middle cerebral artery (MCA), internal carotid artery (ICA), basilar artery and/or vertebral artery and P1 segment of posterior cerebral artery (PCA); 4. Recanalization of blood vessels after operation (mTICI ≥ 2b grade)
Exclusion criteria
1. Placing permanent stents or other implants in the target artery 2. Can not receive HR-VWI examination of 3T MRI due to claustrophobia or unstable condition 3. Contraindications to MRI and/or intravenous gadolinium
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral vascular wall damage | within 5-7 days after MT | Incidence of T1 hyperintensity and T1 shortening within the arterial wall in HR-VWI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Target vessel stenosis rate | Within 5-7 days after MT | The stenosis rate of target blood vessel artery 5-7 days after MT surgery. |
| Perioperative complications | Within 30 days after MT | Cumulative incidence rate of symptomatic intracranial hemorrhage, TIA or ischemic stroke within 30 days after MT surgery. |
| Neurological function evaluation | Within 90 days after MT | Proportion of patients with good prognosis 3 months after MT surgery. |
Countries
China
Contacts
Primary ContactGao-Jun Teng, M.D.
Outcome results
None listed