Nephrotic Syndrome
Conditions
Keywords
renal doppler, nephrotic syndrome, steroid resistance
Brief summary
The use of the renal resistive index in pediatric patient with idiopathic nephrotic syndrome to detect steroid resistance and to use it as a prognostic instrument of the progression of the disease.
Detailed description
Renal Doppler will be done for all children in supine and lateral positions using Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity) at diagnosis, after one month, 3 months and 6months, in which these values will be obtained by the ultrasound machine based on the computer algorithm. Also the kidneys will be scanned firstly for length, width, cortical thickness and echogenicity.
Interventions
DEVICErenal doppler
Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity
Sponsors
Tanta University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric patients with primary nephrotic syndrome aged from 1 to 18 years
Exclusion criteria
* \- Patients with congenital nephrotic syndrome. * Patients with secondary causes of nephrotic syndrome.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| detection of steroid resistance in pediatric patients with idiopathic nephrotic syndrome | 6 weeks | measurement of renal resistive index and detection of steroid sensitivity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| progression of nephrotic syndrome | six months | frequent measurement of renal resistive index and using it as prognostic factor |
Countries
Egypt
Outcome results
None listed