Hyperoxemia
Conditions
Brief summary
The purpose of this prospective randomized controlled trial is to determine whether using the Oxygen Reserve Index can prevent hyperoxemia in pediatric patients receiving single-lung ventilation. Participants will have their FiO2 adjusted in a prescribed manner based on the arm to which they are assigned. The researchers will compare whether blood oxygen levels were lower in the ORI group.
Interventions
PROCEDURETitration of FiO2
The inhaled oxygen concentration after one-lung ventilation will be treated by the group.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 7 Years
Healthy volunteers
No
Inclusion criteria
* Children under 7 years of age undergoing surgery under unilateral pulmonary ventilation * Children with American Society of Anesthesiology physical status I, II, III
Exclusion criteria
* Patient who have chronic respiratory failure * Patient who have a history of bronchopulmonary dysplasia, respiratory distress syndrome of neonate, laryngomalacia, tracheomalacia or tracheal stenosis * Patient whose initial Oxygen Reserve Index value is zero * Patient who need supplementary oxygen before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of moderate to severe hyperoxemia in arterial blood gas analysis at T2 (30 minutes after one lung ventilation) | 30 minutes after initiation of one-lung ventilation | arterial oxygen content over 200 |
Secondary
| Measure | Time frame |
|---|---|
| average Oxygen Reserve Index value | during one lung ventilation |
| time-weighted average inspired oxygen fraction | during one lung ventilation |
| incidence of hypoxemia | perioperative period |
| incidence of perioperative complications | perioperative period |
Countries
South Korea
Outcome results
None listed