Sarcopenia
Conditions
Brief summary
The purpose of this study was to investigate the effects of Pennisetum purpureum health food supplementation on muscle mass and muscle strength.
Detailed description
All participants performed anthropometric measurements (body height, body weight, BMI, blood pressure, body composition, upper arm circumference, and lower thigh circumference), blood collection (hormones, liver function, and kidney function), exercise test (grip strength and 10-m walking test), as well as questionnaire survey before supplementation. Participants were assigned to either the experimental (n=20) or placebo (n=20) group according to their body composition, upper arm circumference, and lower thigh circumference. The definition of insufficient muscle mass was based on the Asian working group for sarcopenia (AWGS) that skeletal muscle mass in extremities by dual-energy X-ray absorptiometry less than 7.0 kg/m2 in men and less than 5.4 kg/m2 in women is a necessary condition, and one of the following criteria were met: (1) handgrip strength less than 28 kg in men and less than 18 kg in women and (2) 5-time chair stand test over than12 seconds. The anthropometric measurements (body height, body weight, BMI, blood pressure, body composition, upper arm circumference, and lower thigh circumference), blood collection (hormones, liver function, and kidney function), exercise test (grip strength and 10-m walking test), as well as questionnaire survey, were collected after 8 weeks and 12 weeks of supplementation.
Interventions
DIETARY_SUPPLEMENTPennisetum purpureum
300mg Participants received 900mg of Pennisetum purpureum orally daily for 12 weeks
DIETARY_SUPPLEMENTPlacebo
Placebo
Sponsors
Taipei Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
A double-blind, matched-pair study design
Intervention model description
Participants were assigned to either the experimental (n=20) or placebo (n=20) group according to their body composition, upper arm circumference, and lower thigh circumference.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. adult between 18-75 years old 2. skeletal muscle mass in extremities by dual-energy X-ray absorptiometry less than 7.0 kg/m2 in men and less than 5.4 kg/m2 in women 3. one of the following criteria were met: (1) handgrip strength less than 28 kg in men and less than 18 kg in women and (2) 5-time chair stand test over than 12 seconds
Exclusion criteria
1. The volunteers have history of cardiovascular, liver, kidney, and diabetes mellitus 2. acute sport injury 3. participated in any clinical trials or experimental research in the last 3 months before our experiment 4. taking supplement during the experimental period 5. did not maintain their regular eating habit or drink alcohol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body height | Baseline (before supplementation) |
| Body weight | Baseline (before supplementation) |
| BMI (body mass index) | Baseline (before supplementation) |
| Systolic blood pressure | Baseline (before supplementation) |
| Diastolic blood pressure | Baseline (before supplementation) |
| ASM (Appendicular Skeletal Muscle Mass) | 12 weeks of supplementation |
| Upper Arm Circumference | Baseline (before supplementation) |
| Thigh Circumference | Baseline (before supplementation) |
| Grip Strength | Baseline (before supplementation) |
| 10-Meter Walk Test | Baseline (before supplementation) |
| Testosterone level | Baseline (before supplementation) |
| Cortisol level | Baseline (before supplementation) |
| Growth Hormone level | Baseline (before supplementation) |
| Insulin-like Growth Factor-1 | Baseline (before supplementation) |
| follistain level | Baseline (before supplementation) |
| myostain level | Baseline (before supplementation) |
Countries
Taiwan
Contacts
Primary ContactMing Ta Yang, Doctorate
Outcome results
None listed