Autism Spectrum Disorder
Conditions
Keywords
Autism Spectrum Disorder, Oral microbiota, Oral Health
Brief summary
The goals of this pilot study are to assess the presence of harmful germs for gums and to assess oral health in adults with autism spectrum disorder.
Detailed description
Participants or their tutors will fulfill a form with general health information and daily habits. Investigators will : * collect saliva, gum fluid and/ or dental plaque to characterise germs * assess gum health and oral hygiene * register decays, filled and missing teeth.
Interventions
OTHERcollection of saliva, gum fluid and/or dental plaque samples
Non-invasive sampling of dental plaque, crevicular fluid and/or saliva, using an examination probe, paper tips and saliva swabs
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
No Treatment
Intervention model description
Pilot study concerning adults with autism spectrum disorder
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* A person (or legal representative) who has received full information about the organisation of the research and accept to participate and the use of his or her data. * Adult with autism spectrum disorder, men or women aged between 18 and 60. * Member of a social security scheme or beneficiary of a medical insurance
Exclusion criteria
* Children under 18 with autism spectrum disorder * Use of medication or situations that may affect the microbiota (use of antibiotics, probiotics, steroidal or non-steroidal anti-inflammatory drugs in the last 3 months, strict mouth breathing) * Smoking * Very lingual position of the teeth hindering clinical assessment of the periodontium * Patients who have had periodontal treatment for less than 6 months * Persons covered by articles L. 1121-5 to L. 1121-7 and L1122-2 of the French Public Health Code: * Pregnant women, women in labour or breast-feeding mothers * Persons deprived of their liberty by a judicial or administrative decision * Persons unable to give their consent * Person under psychiatric care by virtue of articles L. 3212-1 and L. 3213-1 of the Public Health Code * Minor (not emancipated)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of periodontopathogenic bacteria (harmful for gums) | Collection on Day 1 | Technique used = Polymerase Chain Reaction (PCR) Measure unit = Colony-Forming Unit (CFU) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the presence of parasites Entamoeba gingivalis subtype 1 (ST1) and subtype 2 (ST2) and Trichomonas tenax | Collection on Day 1 | Technique = Polymerase Chain Reaction (PCR) Unit = Colony-Forming Unit (CFU) |
| Assessment of the periodontal status of patients with Autism Spectrum Disorder | Day 1 | Index used = the Dutch Periodontal Index 0 = minimum value, better outcome 4 = maximum value, worse outcome |
| Assessment of the dental condition | Day 1 | Dental data will be collected using the Decay-Missing-Filled/Teeth (DMFT) score 0 = minimum value, best outcome 28 = maximum value, worst outcome |
| Assessment of oral hygiene | Day 1 | Oral hygiene will be assessed using the Silness and Löe plaque index and the lifestyle questionnaire 0 = minimum value, best outcome 3 = maximum value, worst outcome |
| Collection of data about lifestyle habits (oral and dental hygiene, diet, activity, etc.) and drug treatments that may influence the clinical parameters observed | Before samples collection and clinical examination | Data collection via a form fulfilled by the participant or the patient's legal guardian |
Countries
France
Outcome results
None listed