Myofibrillation, Succinylcholine
Conditions
Brief summary
Succinylcholine is an important component of rapid sequential induction of general anesthesia because of its rapid onset and short duration of action. However, myofibrillation is a common complication after succinylcholine injection and may lead to persistent postoperative myalgia, increased intraocular, intragastric and intracranial pressure in patients. Increased risk of peri-induction and postoperative patient discomfort. The effectiveness of rocuronium bromide pretreatment in reducing succinylcholine-induced myalgias has been demonstrated in several recent studies. However, the half effective amount of rocuronium pretreatment for small doses is not well known. Therefore, this study applied the Dixon sequential method to investigate the ED50 of preemptive intravenous rocuronium bromide for the prevention of succinylcholine-induced myofibrillation and to investigate the effect of age factor on the ED50 of rocuronium bromide for the prevention of succinylcholine-induced myofibrillation to provide a reference for the rational clinical selection of rocuronium bromide dose.
Interventions
DRUGrocuronium
Advanced intravenous injection of rocuronium before the succinylcholine injection
Sponsors
Yangzhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Ages ranged from 18 to 80. 2. ASA grade I-II
Exclusion criteria
1. Possible airway difficulties, 2. allergies or contraindications to rocuronium and succincholine ， 3. cardiac insufficiency, 4. hepatic or renal dysfunction, 5. neuromuscular disease, 6. surgery lasting more than 2 hours, 7. taking any known drug that has interaction with neuromuscular blockers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The appearance of myofibrillation | Average 45 seconds | Yes or No |
Countries
China
Outcome results
None listed