Skip to content

Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy

The Effect of Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy in Patients With Periodontitis

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05907161
Enrollment
45
Registered
2023-06-18
Start date
2023-06-09
Completion date
2026-02-28
Last updated
2025-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Brief summary

Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket. In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects. Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.

Detailed description

Each participant will be assigned in one of three groups. In each group there will be 15 participants. Different treatment protocols will be carried in each group as follows: group one (scaling and root planing), group two (scaling and root planing + LASER), group three (scaling and root planing + hyaluronic acid). Under local anesthesia we will perform scaling and root planing of the teeth in two sessions. The procedure be made with the use of ultrasonic (PiezoLED Scaler, KaVo, Biberach, DE) and hand instruments (Gracey, Hu Friedy, Chicago, IL, USA). In group one, only scaling and root planning (SRP) will be made. In group two, the use of a diode laser (Dentsply Sirona - SIROLaser Blue) will be added to the therapy. In group three, after the performance of SRP, a gel containing hyaluronic acid (Regedent, HyaDENT Cross linked hyaluronic acid gel) will be applied intrasulcular.

Interventions

DEVICESRP+LASER (Dentsply Sirona - SIROLaser Blue)

adjunct irradiation with a diode laser (Dentsply Sirona - SIROLaser Blue) intrasulcularly to all sites with PD ≥ 4mm

DEVICESRP+HA

adjunct hyaluronic acid (Regedent, HyaDENT Cross linked hyaluronic intrasulcularly to all sites with PD ≥ 4mm

DEVICESRP

non-surgical periodontal therapy (SRP) with utrasonic device and curretes

Sponsors

University Medical Centre Ljubljana
CollaboratorOTHER
University of Ljubljana
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)

Masking description

Before initial treatment the care provider will randomly pick an envelope with one of the three treatment modalities. At follow-up visits the investigator will perform the periodontal examination without having access to the patients data.

Eligibility

Sex/Gender
ALL
Age
25 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* systemically healthy * nonsmokers * untreated periodontal disease (stage 3, grade B or C) * plaque index will not exceed 20% * at least 20 teeth in oral cavity

Exclusion criteria

* systemic diseases with impact on periodontal health * medication with impact on periodontal health * smokers * pregnant and lactating women * patients treated with antibiotics in the last 12 months * patients who had undergone periodontal treatment in the last year

Design outcomes

Primary

MeasureTime frameDescription
Probing pocket depth reduction3 months, 6 monthsChange in probing pocket depth after treatment

Secondary

MeasureTime frameDescription
Clinical attachment level gain3 months, 6 monthsChange in clinical attachment level after treatment
Bleeding on probing percentage reduction3 months, 6 monthsBleeding after measurement of pocket depth, reduction after treatment
Residual diseased site number3 months, 6 monthsNo of sites with PD ≥ 4mm and bleeding on probing after treatment

Countries

Slovenia

Contacts

Primary ContactEva Skaleric, Dr.
eva.skaleric@gmail.com0038640813432
Backup ContactAleš Fidler, Dr.
ales.fidler@gmail.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026