Liquid Biopsy, Melanoma (Skin)
Conditions
Brief summary
The goal of this Interventional study aims to apply, in our Institutes, a 4p oncological model i.e. predictive, personalized, of precision and participated (Regina Elena and San Gallicano).
Detailed description
Patients will be recruited with an innovative and systematic scheme: collection and biobanking of biological materials (tissue biopsy, re-biopsy and liquid biopsy) followed by a molecular monitoring thanks to genomic and epigenomic methods. It's an open-ended study. In particular we will try to identify new actionable signatures and we will try to insert the patients to innovative clinical trials, thanks to the evaluation of all cases with a Molecular Tumor Board. The main objectives are: * Introduce a new methodology to improve and integrate the already existent institutional PDTA * Evaluate and measure the applicative value * Establish a biostatistical platform
Interventions
DIAGNOSTIC_TESTBiopsy
Liquid biopsy, re-biopsy, tissue biopsy
Sponsors
Istituti Fisioterapici Ospitalieri
Regina Elena Cancer Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
The recruiting of two simultaneous cohorts is scheduled. a) patients of illness onset (Cohort 1); b) patients with locoregional disease and/or metastatic designed for systemic therapies (cohort 2).
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Melanoma affected patients
Exclusion criteria
* No patiens affected by other pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oncology target therapy | 12 months | Integration between molecular diagnostic and melanoma histopathology: correlation between mutational miRNA/ncRNA profiles and pathological staging parameters. |
Countries
Italy
Contacts
Primary ContactPatrizio Giacomini, MD
Backup ContactEmilia Migliano, MD
Outcome results
None listed