Cataract, Myopia
Conditions
Keywords
antioxidants
Brief summary
This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.
Interventions
PROCEDURECataract surgery, Femtosecond-LASIK, SMILE
Cataract surgery includes both conventional and femtosecond laser assisted. Femtosecond-LASIK and SMILE are options for patients to correct myopia.
Sponsors
Nobel Eye Institute
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* over 20 years old (included) * corneal refractive surgery or cataract surgery patients
Exclusion criteria
* patients with eye infections * presence of severe retinal disease * presence of severe eye injury or severe ptosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of Ascorbic Acid (AA) in aqueous humor from Baseline to one day after surgery. | During the operation and one day after surgery. |
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 month after surgery. | Before the operation and 1 month after surgery. |
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 week after surgery. | Before the operation and 1 week after surgery. |
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 3 months after surgery. | Before the operation and 3 months after surgery. |
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 6 months after surgery. | Before the operation and 6 months after surgery. |
| Change of Ascorbic Acid (AA) in tears from Baseline to 1 week after surgery. | Before the operation and 1 week after surgery. |
| Change of Ascorbic Acid (AA) in tears from Baseline to 1 month after surgery. | Before the operation and 1 month after surgery. |
| Change of Ascorbic Acid (AA) in tears from Baseline to 3 months after surgery. | Before the operation and 3 months after surgery. |
| Change of Ascorbic Acid (AA) in tears from Baseline to 6 months after surgery. | Before the operation and 6 months after surgery. |
| Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery. | During the operation and one day after surgery. |
Secondary
| Measure | Time frame |
|---|---|
| Examination of uncorrected visual acuity (UCVA). | Before the operation. |
| Examination of intraocular pressure (IOP). | Before the operation. |
| Examination of central corneal thickness (CCT). | Before the operation. |
| Examination of axial length (AXL). | Before the operation. |
| Examination of anterior chamber depth (ACD). | Before the operation. |
| Examination of lens thickness (LT). | Before the operation. |
| Examination of manifest refraction. | Before the operation. |
| Examination of corneal curvature. | Before the operation. |
| Examination of best corrected visual acuity (BCVA). | Before the operation. |
Countries
Taiwan
Outcome results
None listed