Alveolar Bone Resorption
Conditions
Keywords
alveolar ridge preservation, Bio-OSS Collagen, sticky bone
Brief summary
In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the Bio-Oss Collagen underwent alveolar ridge preservation using Bio-Oss Collagen and the Sticky Bone group using Sticky Bone, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation
Detailed description
Within 6 months after tooth extraction, the remaining alveolar ridge undergoes varying degrees of absorption, resulting in a decrease in horizontal width and vertical height of the alveolar ridge. The three-dimensional size change of the alveolar socket may affect the implantation of later implants and cause aesthetic and functional problems. Alveolar ridge preservation can maintain the volume of the alveolar socket, prevent soft tissue from growing into undesirable positions, slow down the absorption of the alveolar ridge to some extent, promote new bone formation, and maintain the shape of the extraction socket. This is crucial for later implant treatment for missing teeth. In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the Bio-Oss Collagen group underwent alveolar ridge preservation using Bio-Oss Collagen and the Sticky Bone group using Sticky Bone, respectively, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation
Interventions
PROCEDUREalveolar ridge preservation with bio-oss collagen
Alveolar ridge preservation with bio-oss collagen is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting bio-oss collagen in the socket and covering the biological barrier membrane.
PROCEDUREalveolar ridge preservation with sticky bone
Alveolar ridge preservation with sticky bone is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting sticky bone in the socket and covering the biological barrier membrane.
Sponsors
Second Affiliated Hospital, Zhejiang University, School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
Clinical assessments, semi-quantitative histological analysis, and statistical analysis were performed by examiners who were blinded to treatment allocation.
Intervention model description
The control group underwent natural healing, and the experimental group underwent alveolar ridge preservation using Bio-Oss Collagen and Sticky Bone, respectively.
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1. The presence of one adjacent tooth at the extraction site 2. Adequate oral hygiene (plaque index \<20%;bleeding on probing \<25% ) 3. Need for tooth extraction due to endodontic，periapical or periodontal disease. 4. Presence of ≥ 2 mm of keratinized tissue 5. the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls)
Exclusion criteria
1. Pregnancy or lactation 2. Smoking more than 10 cigarettes per day 3. with no evidence of acute infection such as severe swelling, suppuration at the extraction site 4. Uncontrolled periodontal disease 5. Existence of bone metabolic disease 6. history of malignancy, radiotherapy, or chemotherapy in the past 5 years 7. Administration of bisphosphonates 8. long-term use of NSAIDs 9. Alcohol or drug abuse 10. Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS) 11. Uncontrolled severe diabetes.( hemoglobin A1c \>6.7%)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in horizontal ridge widths | baseline (before the surgery) and six months | Changes in horizontal ridge widths at 1, 3, and 5 mm below the ridge crest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the vertical heights of the ridge | baseline (before the surgery) and six months | Changes in the vertical heights of the ridge at the buccal and lingual crest areas |
| Thicknesses of the keratinized gingiva | baseline (before the surgery) and six months | Thicknesses of the keratinized gingiva at 2 and 4mm below the highest point of the gingiva |
| width of the keratinized gingiva | baseline (before the surgery) and six months | width of the keratinized gingiva |
| percentages of newly formed bone | six months | percentages of newly formed bone and residual bone substitute material in histologic sections |
| The percentage of residual materials | six months postoperative | — |
| The bone density ratio | six months postoperative | — |
| The percentage of in alveolar bone volume within the region of interest (ROI) relative to the volume | at baseline | — |
| Postoperative response assessed by the Visual Analogue Scale (VAS) questionnaire | one week post-surgery | — |
| Changes in thickness of the peri-implant mucosa | at implant placement and one year after crown placement | Changes in buccolingual thickness of the peri-implant mucosa at 2 mm apical to the mucosal margin |
| Changes in marginal bone level | at crown placement and one year after crown placement | Changes in marginal bone level |
| Changes in peri-implant buccal bone thickness | at implant placement and one year after crown placement (T6). | Changes in peri-implant buccal bone thickness at 2 mm apical to the implant shoulder |
| Bleeding on probing and probing pocket depth | one year after crown placement | Bleeding on probing and probing pocket depth |
Countries
China
Contacts
STUDY_DIRECTORLi Li Zhou, doctor
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Outcome results
None listed