Breast Cancer
Conditions
Keywords
Imaging
Brief summary
This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.
Detailed description
PRIMARY OBJECTIVE: I. To determine feasibility of acquiring MRI simulation prior to RT planning. EXPLORATORY OBJECTIVE: I. To determine change in target volume with MRI simulation compared to Computerized tomography (CT) simulation. OUTLINE: MRI simulation will be performed once at baseline. There is no follow up planned for study purposes. Patients will be followed as part of their regular clinical care.
Interventions
DIAGNOSTIC_TESTMagnetic Resonance Imaging Simulation
Radiographic Image Simulation
Sponsors
University of California, San Francisco
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Participants with an Eastern Cooperative Oncology Group (ECOG) performance status \<=2 (or Karnofsky ≥\>=60%, see Appendix A). 2. Participants with the ability to understand and the willingness to sign a written informed consent document. 3. Participants may separately enroll on therapeutic clinical trials when they enroll on this trial. Note: All interventions on this protocol are standard of care, so enrollment on other therapeutic protocols is allowed at the discretion of the treating physician. 4. Patients must have pathologically confirmed invasive or in situ breast cancer. 5. Patients must have tumors in which adjuvant breast radiotherapy following breast conserving surgery is indicated, as determined by the treating physician. 6. Patients must be female. Note: Male patients are excluded due to the rarity of male breast cancer and difficulty in pursuing breast conserving surgery for male patients.
Exclusion criteria
1. Participants with a contraindication to MRI per the MRI checklist. 2. Patients with breast tumor or tumor bed not visualized at CT or MRI during RT planning.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of participants who completed scan | Day of MR imaging (1 day) | Feasibility feasibility of acquiring MRI simulation prior to RT planning is defined as successfully acquiring MRI data at the specified time point in a participant's radiotherapy (RT) care plan |
Countries
United States
Contacts
CONTACTImani Dunn
PRINCIPAL_INVESTIGATORLisa Singer, MD, PhD
University of California, San Francisco
Outcome results
None listed