Yellow Fever
Conditions
Brief summary
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
Detailed description
No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.
Interventions
DRUGYellow Fever Vaccine
vaccination according to manufacturers manual (0.5mL subcutaneously in the arm)
Sponsors
The International Society of Travel Medicine
Leiden University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
human infection model of yellow fever with the yellow fever 17D vaccine and viruria (virus in urine) as readout
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-50 years
Exclusion criteria
* contraindication to receive YF-17D (immune deficiency, thymus illness) * previous YF vaccination * pregnancy * chicken egg allergy * hypersensitivity to any other substance in the YF-17D vaccine * interval of \< 4 weeks of another live attenuated vaccine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| yellow fever 17D in urine | within 30 days of the vaccination | yellow fever 17D in urine at sequential time points after vaccination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| peak of YF 17D viruria after vaccination | within 30 days of the vaccination | days after vaccination on which most participants have a positive yellow fever virus PCR on urine as material |
| YF-17D viremia (in plasma) after vaccination | within 14 days of the vaccination | days after vaccination on which most participants have a positive yellow fever virus PCR on plasma as material |
Countries
Netherlands
Contacts
Primary ContactAnna H Roukens, MD, PhD
Backup ContactLeo G Visser, MD PhD
Outcome results
None listed