Poor Responders
Conditions
Keywords
Cetrorelix, DHEA, somatotropin, myo inositol
Brief summary
To evaulate the role of Myo-inositol, somatropin, DHEA on ICSI outcome in poor ovarian responder
Detailed description
Each patient will be subjected to: Full history taking. Systematic clinical examination to assess the general condition, body mass index (BMI) and local pelvic physical findings and AFC by trans-vaginal ultrasound on D2 to 3 of menstruation. Routine labs as CBC, liver & kidney functions to exclude general disease as a contraindication for induction or pregnancy. Blood sample will be obtained for assessment of basal serum levels of FSH, LH, E2 on days 2- 3 of the cycle. PRL, AMH and TSH Ovarian Stimulation The patients will begin injections of recombinant FSH (rFSH, Gonal-F; Merck-Serono, Italy) from day 2-3 of menstruation, with daily dose of 150-300 IU adjusted according to individual conditions on the basis of the antral follicle count (AFC),hormonal profile, age, body mass index (BMI), and previous ovarian response, according to the standard operating procedures of the center. . For pituitary suppression, the patients will receive GnRH antagonist Cetrorelix (CETROTIDE 0.25Mg/d, Merck Serono, Germany) 0.25 mg/day subcutaneously from day 6 of induction until trigger day. The serum LH, estradiol levels as well as number and size of follicles will be monitored every two days, starting from stimulation day 6 until the day of hCG injection.
Interventions
DRUGmyo-inositol
myo-inositol 600µgm + folic acid 0.2 mg) 2 capsules at the morning and 2 capsules at the evening on empty stomach for 12 weeks produced by a Lo.Li pharma international ,Rome.Italy .
DRUGSomatropin
growth hormone 2:Somatropin (4 IU for 1month), SEDICO ,6th of october .Egypt. 1 s.c injection every 3 days for at least 1 month.
DRUGDehydroepiandrosterone
DHEA 50 mg twice per day for 12 weeks in the last group , NATROL UK.Ltd.
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 1-Infertile women who have one of the criteria of poor ovarian response as follows ; * Antral follicle count less than 7 * Anti-Mullerian hormone level Less than 1.2 ng/ml 2- females with body mass index (BMI) from 19-25
Exclusion criteria
1. Any endocrine or metabolic disorder such as polycystic ovary syndrome, 2. Hyperprolactinemia, diabetes and thyroid dysfunction. 3. Any pelvic pathology such as hydrosalpinx, uterine anomaly. 4. any male factor infertility such as Oligo-Astheno-Teratozoospermia (OAT) or Azoospermia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number and maturity of oocytes retrieved | 1 month | Number and maturity of oocytes retrieved (M1/M2) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| chemical pregnancy rate | 1 month | hcg positive |
Countries
Egypt
Contacts
Primary ContactSara A Salem, MD
Outcome results
None listed