Dental Implant Infection
Conditions
Brief summary
This study aims to: 1. To identify the most common organisms causing dental implant failure. 2. Set an appropriate antibiotic regimen according to the causative organism to limit the antimicrobial resistance by limit the use of antibiotics.
Detailed description
Dental implant surgery is a common treatment for replacing missing teeth and has a high success rate. Implant failure is most likely the result of multiple factors as Age, sex, smoking, maxillary implant site, quantity and quality of bone, implant surface treatments and features are some of the statistically examined parameters linked to implant failure. The most frequent and avoidable cause of dental implant failure is infection. A retrospective analysis demonstrated fewer numbers of early implant failures among those that were placed under antibiotic treatments. Early implant failure is commonly associated with certain strains of bacteria. The most common bacteria involved are streptococci, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods.Porphyromonas gingivalis and Fusobacterium nucleatum frequently colonize the implant in early and late losses and could therefore be characteristic for implant loss in general. Thus, the antibiotic to prevent delayed healing of wound should be bactericidal and of low toxicity. Systemic antibiotic prophylaxis has been used to reduce the risk of early implant failure and local infections around dental implants.Antibiotics are one of the most cost-effective, life-saving medicines and contribute to an extended lifespan. Access to antibiotics without a prescription is a driving factor for irrational antibiotic use due to a potential lack of access to proper diagnosis and diagnostic tools. This eventually leads to the development and spread of antibiotic resistance &it is one of the increasing public health challenges worldwide.
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
Saliva samples from patients seeking dental implant procedures \-
Exclusion criteria
* Immunodeficiency or immunosuppressing treatment * current antibiotic treatment * smoking * acute or chronic oral infection (including ongoing periodontal infection).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to limit the antimicrobial resistance by identifying the most suitable antibiotic regimen according to the intra-oral organisms | september 2023-september 2024 | according to the antibiogram at least 30 isolates from each species are needed to identify the most common organisms and set an appropriate antibiotic regimen for patients seeking dental implants.An antibiogram is an overall profile of antimicrobial susceptibility testing results of a specific microorganism to a battery of antimicrobial drugs. This profile is generated by the laboratory using aggregate data from a hospital or healthcare system; data are summarized periodically and presented showing percentages of organisms tested that are susceptible to a particular antimicrobial drug |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to prevent dental implant failure by setting the most suitable antibiotic regimen according to the intra-oral micro-organisms | through the study completion, an average of one year. | the investigator can define and set antibiotic regimen to the oral micro-organisms by the antibiogram .The Clinical and Laboratory Standards Institute (CLSI; formerly NCCLS) published guidelines entitled Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data for use when creating an antibiogram. CLSI guidelines recommend compiling the antibiogram at least annually, including only the first isolate per patient in the period analyzed, and including only organisms for which ≥30 isolates were tested in the period analyzed. |
Contacts
Primary Contactsalma mohamed, master
Backup Contactheba rashed, professor
Outcome results
None listed