Resistant Arterial Hypertension
Conditions
Keywords
antihypertensive drugs, concentration, HPLC MS/MS
Brief summary
This study was planned to assess the concentration of antihypertensive drugs in the blood plasma in patients with controlled and uncontrolled arterial hypertension. Methods: it is planned to include patients with arterial hypertension taking 3 antihypertensive drugs (indapanide, lisinopril or valsartan, amlodipine). Based on the results of 24-hour blood pressure monitoring, the patients will be randomized into two groups: The first group - the patients with controlled AH; The second group - the patients with uncontrolled AH. Venous blood was taken in both groups of the patients in the morning before and 2 hours after taking drugs to assess the concentration of lisinopril, amlodipine, valsartan and indapamide. Concentation of assesed antihypertensive drugs will be compared in both groups.
Interventions
DIAGNOSTIC_TESTBlood samples will be taken for pharmacokinetics and pharmacogenetics
To assess antihypertensive drugs concentration (lisinopril, valsartan, amlodipine, indapamide
Sponsors
Ryazan State Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signed informed consent form; * An established diagnosis of AH based on the Clinical Guidelines Arterial hyperten-sion in adults, approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation, 2020; * Mandatory patient compliance with recommendations for lifestyle modification in accordance with the Clinical Guidelines Arterial hypertension in adults, approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation, 2020 . * Regular administration of any two antihypertensive drugs (lisinopril, amlodipine, valsartan) in combination with indapamide for a month, possibly in fixed combinations, in stable dosages; * Fertile female patients must use proper methods of contraception throughout the study period.
Exclusion criteria
* Patient's connection with the organization or conducting of the study; * Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma Concentration of lisinopril, valsartan, amlodipin, indapamide, metoprolol | day 1 | Number of Participants with antihypertensive drug concentraion below the limit of quantitative determination |
Countries
Russia
Contacts
Primary ContactSergey V Seleznev, MD, PhD
Backup ContactAlexey V Shchulkin, MD, PhD
Outcome results
None listed