Healthy Nutrition
Conditions
Brief summary
The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.
Interventions
OTHERresistance training
All participants perform a four-day resistance training aimed to stimulate a hypertrophic response.
OTHERketogenic diet
Subjects allocated to the ketogenic diet arm (KD group) consume less than 50 g of carbohydrates per day.
OTHERwestern diet
Subjects allocated to the western diet arm (WD group) consume a standard diet based on 55% of their daily calories from carbohydrates.
Sponsors
University of Padova
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* at least 2 years of resistance-training experience * Body mass index: more than 18 kg/m2 and less than 30 kg/m2
Exclusion criteria
* metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc) * experience with the ketogenic diet (last six months) * acute inflammatory status * treatment with steroids in the past 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mammalian target of rapamycin (mTOR) signalling | Change from baseline to 4 weeks | Measurement of the change in muscle protein anabolic signalling pathway in response to a single bout of resistance exercise by western blot analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle mass | Change from baseline to 4 weeks | Measurement of the change in kilograms of muscle mass via Dexa |
Countries
Italy
Contacts
Primary ContactGiuseppe Cerullo
Outcome results
None listed