Anesthesia, Carotid Doppler Ultrasound, Elderly, Flow Time, Hypotension
Conditions
Brief summary
The aim of our study is to determine the predictive value of pre-anesthesia FTc for hypotension that may develop after general anesthesia induction in patients over 65 years of age and to investigate the correlation between pre-anesthesia FTc and the magnitude of the maximum decrease in systolic blood pressure from the pre-anaesthetic value.
Detailed description
The FTc value of the patients to be included in the study will be measured by ultrasonography 10 minutes before the induction of anesthesia.After the measurement, the patients will be monitored with 3-lead electrocardiography, pulse oximetry and noninvasive blood pressure in the operating room. Before induction of general anesthesia, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP), oxygen saturation and heart rate will measured for 3 minutes at 1-minute intervals. Induction of anesthesia with 1-2 mg/kg propofol, muscle relaxation will be achieved with 0.6 mg/kg intravenous rocuronium. During mask ventilation, 1-2% concentration of sevoflurane and 50-50% oxygen-nitrous oxide will be used. After the anesthesia induction, SBP, DBP, MAP, oxygen saturation and heart rate will be measured for 3 minutes at 1-minute intervals. Hypotension; defined as a 30% reduction in SBP or a 20% reduction in MAP, or an absolute SBP below 90 mm Hg and MAP below 65 mm Hg within 3 minutes of induction of general anesthesia.Intravenous (iv) noradrenaline and/or iv crystalloid will be used in the treatment of hypotension.
Interventions
DEVICEultrasound-guided carotid artery flow time measurement
Ultrasound-guided corrected carotid artery flow time will be measured before anestesia induction.
Sponsors
Cukurova University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \>65 years old * undergoing elective surgery under general anesthesia
Exclusion criteria
* Mean arterial pressure \< 70 mmHg * Systolic blood pressure \> 180 mmHg * Diastolic blood pressure \> 110 mmHg * \< 65 years old * Carotid artery stenosis \> 50% * ASA \> 3 * Left ventricle ejection fraction \< 40% * Severe peripheral vascular disease * Implanted pacemacer * Autonomic nervous system disorders * Heart valve disease * Chronic kidney disease * Emergency surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| anesthesia induction related hypotension | at 1 minute after anesthesia induction, at 2 minutes after anesthesia induction, at 3 minutes anesthesia induction | Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP) were measured 1 minute before anesthesia induction and after anesthesia induction (at 1 minute intervals for 3 minutes). Hypotension was defined as 30% decrease in SBP or a 20% decrease in MAP or absolute SBP less than 90 mm Hg, and MAP below 65 mm Hg within 3 minutes of induction of general anaesthesia. |
Countries
Turkey (Türkiye)
Outcome results
None listed