Locally Advanced Rectal Cancer
Conditions
Brief summary
Introduction: In locally advanced rectal cancers (LARC), TNM staging is far from optimal. We aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis. Methods: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centers. A Cox regression and Kaplan-Meier analysis were performed.
Interventions
DIAGNOSTIC_TESTInflammatory markers
analysis of inflammatory scores
Sponsors
Hospital Pedro Hispano
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* patients diagnosed pathologically with rectal adenocarcinomas, located within 12cm from the anal verge (measured by MRI), clinically staged T3-4 and/or N+ and treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery
Exclusion criteria
* evidence of distant metastasis at diagnosis, emergent or palliative surgery, local excision or watch and wait approach and evidence of inflammatory or hematological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival Disease-free survival | 5 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pathological response through Ryan Tumor Regression Grade | at study completion, average of 5 years | TRG 1-5; 1- no viable cancer cells; 5- no fibrosis, with extensive residual disease |
Outcome results
None listed