Regenerative Endodontics in Mature Permanent Teeth

Evaluation of the Effect of Photobiomodulation on Revascularization of Mature Non-vital Permanent Teeth Using Blood Clot as Scaffold

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05892536

Enrollment

Registered

2023-06-07

Start date

2021-01-05

Completion date

2022-01-30

Last updated

2023-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regenerative Endodontics

Brief summary

this study was designed to compare the clinical and radiographic success of REPs after using blood clot scaffold in non-vital mature permanent teeth with or without photobiomodultion therapy

Interventions

PROCEDUREdental regenerative endodontics

regenerative procedures performed in necrotic mature permanent teeth

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

9 Years to 13 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients free from any systemic diseases or genetic disorders. * Children aged 9-13 years old of both sexes. * Traumatically or cariously exposed single rooted mature permanent teeth which may be asymptomatic or manifested with dull ache pain, or spontaneous unprovoked toothache. * Non-vital single rooted mature permanent teeth that indicated for endodontic treatment * Swelling close to involved tooth accompanied with or without fistula. * Negative response to cold & electrical pulp test. * Informed Consent.

Exclusion criteria

* Unrestorable teeth, or that need post and core for the final restoration. * Immature permanent teeth. * Known allergy, sensitivity to ciprofloxacin, metronidazol. * Uncooperativeness of child and/or parents or caregiver's behavior. * Presence of calcific metamorphosis inside root canals.

Design outcomes

Primary

Measure	Time frame	Description
Pulp sensibility	Every 3 months over a period of one year	clinical evaluation of pulp sensibility using electric pulp tester as a measurement tool
Radiographic evaluation of periapical tissues	Every 3 months over a period of one year	Radiographic evaluation using standardized digital radiograph that stored in computer for assessment of periapical tissues status using scoring system: 1. Score 0 - No radiological changes seen compared to preoperative radiograph 2. Score 1 - Slight decrease in radiolucency seen in periapical region 3. Score 2 - Complete reduction or resolution of radiolucency seen in periapical region.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026