Safety and Effectiveness of Ciprofol in Cardiac Surgery Anesthesia

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05892471

Acronym

seccsa

Enrollment

Registered

2023-06-07

Start date

2022-08-01

Completion date

2023-09-01

Last updated

2023-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency. It offers a rapid onset, reduced incidence of injection pain, and minor impact on the cardiovascular system. However, clinical research regarding ciprofol's use for anesthesia induction in cardiac surgery remains limited. The investigators want to assesse the safety and effectiveness of ciprofol in cardiac surgery anesthesia

Interventions

DRUGciprofol injection

Patients in ciprofol group 0.3 mg/kg ciprofol for induction of anesthesia

DRUGPropofol injection

Patients in propofol group received 1.5 mg/kg propofol for induction of anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

55 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. Elective surgery patients 2. Aged 55 to 75 3. New York Heart Association class II or III cardiac functions 4. Median sternotomy approach for coronary artery bypass grafting or heart valve replacement procedures.

Exclusion criteria

1. With a history of benzodiazepine allergy 2. Significant liver or kidney insufficiency 3. Coagulation dysfunction 4. Neurological or psychiatric disorders 5. Undergone major surgery within the past three months.

Design outcomes

Primary

Measure	Time frame	Description
Mean arterial pressure	1 second before induction of anesthesia (T1)	an average blood pressure in an individual during a single cardiac cycle
Heart beats	1 second before induction of anesthesia (T1)	the number of times each minute that heart beats

Secondary

Measure	Time frame	Description
Oxygenation index	1 second before induction of anesthesia (T1)	a calculation used in intensive care medicine to measure the fraction of inspired oxygen (FiO2) and its usage within the body.
Injection pain	During procedure (When injecting the drug, ask the subject if the injection site is painful)	Pain at the injection site when injecting the drug（Evaluation with Visual Analogue Scale）

Countries

China

Contacts

Primary ContactLE YU

907084943@qq.com19921875120

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026