Small Cell Lung Cancer
Conditions
Keywords
Lung Cancer, Small Cell Lung Cancer, Future Research
Brief summary
This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.
Detailed description
The goal of this project to establish a rapid autopsy program in SCLC at the IUSCCC and outline the key components necessary for tumor tissue acquisition. This proposal is a collaboration between scientists, lung cancer physicians, pathologists, and the IUSCCC Translational Research Core. Tumor tissue collected will be used for protein and gene analysis and RNA, whole exome sequencing in addition to the establishment of SCLC. This research is part of a discovery project in which biological and molecular markers of SCLC will be identified.
Interventions
PROCEDUREBiospecimen Collection
Lung, liver, skin, subcutaneous metastases, and blood specimens may be collected via rapid autopsy within 10 hours of expiration.
Sponsors
Indiana University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. ≥ 18 years old at the time of informed consent 2. Written informed consent and HIPAA authorization for release of personal health information. 3. Active SCLC diagnosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determining the Feasibility of the Creation of a Rapid Autopsy Program at IUSCCC for SCLC through enrollment and sample collections | 5 years | — |
| Utilization of Tissue to Better Understand the Complex Biology of SCLC | 5 years | Utilize tissue obtained from rapid autopsies to generate novel patient derived xenograft models and tumor cell lines, in addition to RNA, whole exome and whole genome sequencing, protein extraction to better understand the complex biology of SCLC and set up an infrastructure to develop relevant clinical models that will allow the development of better therapies. |
Countries
United States
Contacts
CONTACTGabby Kline, BA
CONTACTShadia I. Jalal, MD
PRINCIPAL_INVESTIGATORShadia I. Jalal, MD
Indiana University
Outcome results
None listed