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Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence

Detection of Periapical Lesions on Dental Panoramic Images Based on Artificial Intelligence Using Cone Beam Computed Tomography

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05888935
Acronym
OPTITOMO
Enrollment
2000
Registered
2023-06-05
Start date
2022-10-01
Completion date
2027-12-01
Last updated
2026-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical Diseases

Keywords

tomography, dental injury, artificial intelligence, periapical lesions

Brief summary

Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as computed tomography (CT) or cone-beam computed tomography (CBCT). For the radiographic detection of these deep periodontal lesions, the dental panoramic represents a first approach commonly performed with relatively low radiation. The investigation can be followed by retroalveolar radiology imaging that are more localized and more precise. However, using these techniques, the detection rates of these lesions are low (20% and 36% respectively), it is necessary to use three-dimensional tomographic investigation to be more discriminating (69%). The gold standard imaging for detection of these lesions is CBCT followed by retroalveolar radiography (\ 2x less sensitive than CBCT) and panoramic radiography (\ 2x less sensitive than RA). Although not a full-thickness radiograph, the dental panoramic has the advantage of being more commonly performed while being less radiating than CBCT and giving a global view of the dental arches on a single image. The detection of periapical lesions is done after a clinical assessment and a visual appreciation of the complementary examinations. The aim of this project is to improve the detection of periapical lesions, by developing an algorithm able to identify them on a panoramic dental radiograph. This algorithm is based on a deep learning system trained with reference data including panoramic dental imaging and CBCT with an acquisition interval of less than 3 months. The model is based on a previous work, will improve the quality of the initial data (using CBCT), using innovative artificial intelligence algorithms (transfer learning).

Detailed description

The final objective of the research is to improve the early diagnosis of periapical lesions, which would allow a better and faster care of these lesions namely at early stages. This represents a major public health interest since these lesions can be responsible for multiple local and regional pathologies (osteomyelitis, cervico-facial cellulitis, thrombophlebitis, cerebral abscesses...) or even more serious general pathologies (cardiac pathologies, cardiovascular diseases, diabetes, renal diseases, tendinopathies...). For certain target groups such as the military and high-level athletes, this research would make it possible to improve the assessment carried out before medical aptitude or club transfer.

Interventions

None listed

Sponsors

Centre Hospitalier Régional Metz-Thionville
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Patients who have had CBCT and panoramic dental imaging with less than 3 months between the two examinations

Exclusion criteria

* Patients who refused to participe in the study.

Design outcomes

Primary

MeasureTime frameDescription
Artificial Intelligence software performance2 yearsmeasurement of the F1 score. The F1 score is calculated as the harmonic mean of the precision and recall scores. It ranges from 0-100%, and a higher F1 score denotes a better quality classifier.

Secondary

MeasureTime frameDescription
Artificial Intelligence software specificity2 yearsmeasurement of the true positives, true negatives, false positives, false negatives

Countries

France

Contacts

CONTACTArpiné EL NAR, PhD
a.elnar@chr-metz-thionville.fr0033387557766
PRINCIPAL_INVESTIGATORMarc ENGELS-DEUTSCH, MD

CHR Metz Thionville Hopital de Mercy

STUDY_CHAIRPaul RETIF, MD, PhD

CHR Metz Thionville Hopital de Mercy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 25, 2026