CO2 Laser in Scars
Conditions
Brief summary
Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars. Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023. Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is \<25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is \>75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value \<0.05 as significant, was used.
Interventions
PROCEDUREFractional CO2 laser
Patient in group A received FCL treatments four sessions with four weeks apart
PROCEDUREFractional CO2 with Platelet Rich Plasma
Group B received four PRP and FCL sessions 4 weeks apart
Sponsors
Combined Military Hospital Abbottabad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18-50 years * Fitzpatrick skin type III-V * Presented with post-acne, post traumatic or post burn scars * all those patients emotionally balanced with realistic expectations were included in the study.
Exclusion criteria
* scar that was less than 6 months old * if they had an active infection or inflammatory skin condition * having a history of malignancy * a known connective tissue illness * history of excessive bleeding or keloids * unrealistic expectations * pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quartile grading scale for assessment of scars | 16 weeks | Quartile grading scale was used to assess effectiveness of CO2 laser and CO2 laser with Platelet rich plasma in scars.Minimum score=0,Maximum Score=3 .Maximum score means better outcome.The Quartile grading scale (score 0 is \<25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is \>75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. |
Countries
Pakistan
Outcome results
None listed