Epilepsy in Children, Importance of Interictal Epileptiform Activity on Sleep EEG
Conditions
Brief summary
The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.
Interventions
DRUGSulthiame
Sulthiame add-on according to good clinical practice in these childhood epilepsy syndromes
Sponsors
University Hospital, Angers
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 15 Years
Inclusion criteria
* Diagnosis of epilepsy syndromes of childhood with sleep activation * Failure of at least two anti-epileptic drugs (AED) * Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)
Exclusion criteria
* Previous trial with sulthiame * More than 2 AED at inclusion * Use of corticosteroids at inclusion * Change in the anti-epileptic treatment in the 7 days before baseline EEG
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients showing improved sleep EEG at day 14 compared to baseline EEG | 14 days |
Countries
France
Contacts
Primary ContactPatrick Van Bogaert, Professor
Backup ContactElsa Berardi
Outcome results
None listed