Type 1 Diabetes
Conditions
Keywords
exercise, circadian rhythm, glucose control, muscle, strength
Brief summary
The aims of the current study are 1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes. 2. to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes
Interventions
BEHAVIORALMorning exercise
Between 6-10am participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)
BEHAVIORALAfternoon exercise
Between 4-8pm participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)
BEHAVIORALHabitual physical activity levels
Participants will be asked to maintain their normal activity levels
Sponsors
Dasman Diabetes Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
1:1:1 parallel group design
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Physician confirmed type 1 diabetes for at least 1 year * Stable insulin therapy for 3 months prior to the study
Exclusion criteria
* BMI of 45 or higher * BP of 160/100mmHg or higher * autonomic neuropathy * severe proliferative retinopathy * joint or limb injuries preventing weight-bearing activity * autonomic neuropathy * severe proliferative retinopathy * any other medical condition that prevents participants from exercising safely.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle strength | Change from baseline to 12 weeks | Sum of one repetition maximum for the 7 resistance exercise |
| Change in interstitial glucose time in range | Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session | Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in physical function | Change from baseline to 12 weeks | Measured by the short performance physical battery |
| Change in HbA1c | Change from baseline to 12 weeks | HbA1c concentration |
| Change in interstitial glucose average | Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session | Interstitial average glucose measured via continuous glucose monitoring |
| Change in appendicular skeletal muscle mass | Change from baseline to 12 weeks | Measured by DEXA |
| Change in interstitial glucose time in hypoglycaemia | Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session | Interstitial glucose time in range (\<3.9mmol/L) measured via continuous glucose monitoring |
| Change in interstitial glucose time in hyperglycaemia | Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session | Interstitial glucose time in range (\>10mmol/L) measured via continuous glucose monitoring |
| Change in interstitial glucose variability | Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session | Interstitial glucose variability measured via continuous glucose monitoring |
| Change in whole body fat mass | Change from baseline to 12 weeks | Measured by DEXA |
Countries
Kuwait
Contacts
Primary ContactEbaa AlOzairi, MBChB
Outcome results
None listed