Cow's Milk Allergy
Conditions
Brief summary
Cow's milk protein allergy is a sensitivity reaction against cow's milk protein and and is calcified as IgE-medaited, non- IgE mediated and mixed type according to the underlying immunological mechanism. Cow's Milk related Symptom Score ( CoMiSS) Considers general manifestation and dermatological, gastrointestinal and respiratory symptoms.
Interventions
OTHERstool analysis , CBC, specific IgE FOR Cow milk protein allergy
apply CoMiSS and food challenge test on patient whom suspected to have cow milk protein allergy.
Sponsors
Sohag University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 5 Years
Inclusion criteria
: * Age: from birth up to five years... * Sex: both Males and females * All children who suspected to have Cow's Milk Allergy that have the following symptoms (chronic unexplained failure to thrive, regurgitation , chronic abdominal distension, skin manifestation such as urticaria & eczema and respiratory symptoms such as chronic cough, recurrent wheezy chest).
Exclusion criteria
* Functional GIT disorders such irritable bowel syndrome , Gastroesophageal reflux disease according to Rome IV criteria in children * Organic gastrointestinal diseases like coeliac disease , cystic fibrosis. * Chronic gastrointestinal infections as parasitic infections.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| patient who are diagnosed as cow milk protein allergy by CoMiss | one year | measure the accuracy percentage (%) of the Cow's milk-related symptoms score in diagnosis of cow milk allergy at pediatrics department in Sohag hospital university |
| interpretation of the Cow's milk-related symptoms score | one year | The scoring ranges from 0 to 33. Each symptom has a maximal score of 6, except respiratory symptoms where the maximal score is 3. * If final score \> 12, the symptoms are likely cow's milk related. This could potentially be CMPA. * If final score \< 12, the symptoms are less likely related to cow's milk. Look for other causes. * CMPA diagnosis can only be confirmed by an elimination diet followed by an oral food challenge. |
| Food Challenge Test | one year | positive or negative Food Challenge Test |
Countries
Egypt
Contacts
Primary ContactHend A Saber, assistant lecturer
Backup ContactMohammed A Mohammed, professor
Outcome results
None listed