Photoaging
Conditions
Keywords
Carotenoid, Astaxanthin, Skin, Hydration, Elasticity
Brief summary
This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.
Interventions
DIETARY_SUPPLEMENTAstaxanthin 6 mg daily
Astaxanthin at 6 mg is given for daily ingestion and compared against placebo.
DIETARY_SUPPLEMENTPlacebo
Placebo
Sponsors
AstaReal
Integrative Skin Science and Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Astaxanthin vs Placebo
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Females who are 30 to 55 years of age * Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6
Exclusion criteria
* Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene). * Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment * Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study. * New supplementation within 4 weeks with tocopherol * Individuals who are unwilling to stay consistent with a facial cleansing regimen. * Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment * Individuals who are pregnant or breastfeeding. * Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study. * Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin Hydration | 8 weeks | Skin hydration measured with a non-invasive device, SkinMoistureMeterSC |
| Skin elasticity | 8 weeks | Skin elasticity measured with a non-invasive device, Skin Elastimeter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Facial pigmentation | 8 weeks | Facial pigment as measured by BTBP facial imaging analysis |
| Facial redness | 8 weeks | Facial pigment as measured by BTBP facial imaging analysis |
Countries
United States
Contacts
Primary ContactRaja Sivamani, MD
Outcome results
None listed