Central Airway Obstruction
Conditions
Brief summary
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the laser mode is activated on the Monsoon jet ventilator. Ventilation is continued during laser mode.
Interventions
OTHERNo intervention
This is an observational study
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified. * 18 years or older * Need rigid bronchoscopy as pre-determined by the interventional pulmonologist
Exclusion criteria
* Refusal to sign consent * Pregnant patients * Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm * Respiratory instability defined as SpO2<90% with >90% supplemental oxygen. * Ineligible for rigid bronchoscopic intubation * Latex allergy * Evidence of fistulous airway * Active Bronchopleural fistula
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time in seconds to AiO2 from 90 to 40% | baseline | Time in seconds to AiO2 from 90 to 40% after activating laser mode on the monsoon jet ventilator. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences in time to laser mode AiO2 | baseline | Differences in time to laser mode AiO2 between trachea and left and right mainstem bronchi. |
Countries
United States
Contacts
Primary ContactCandace Nelson
Outcome results
None listed