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Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women

Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women. A Randomized, Crossover, Double-blind, and Placebo-controlled Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05880186
Acronym
CIRCAF_WOM
Enrollment
14
Registered
2023-05-30
Start date
2021-02-09
Completion date
2021-04-09
Last updated
2023-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Supplement

Brief summary

Caffeine is a natural stimulant with well-recognized metabolic benefits, however, there is a lack of studies investigating the time-of-day caffeine influence to enhance fat oxidation in women. The aim of this study was to evaluate the influence of the time of the day on the effect of caffeine on maximal rate of fat oxidation during aerobic exercise in women.

Detailed description

Caffeine is a natural stimulant with well-recognized sports performance benefits. Aside its performance-enhancing effect, caffeine has the potential of increasing fat utilization during aerobic exercise at submaximal intensities, lowering-down the contribution of carbohydrate as a fuel. This property of caffeine may provoke a glycogen-sparing effect in the skeletal muscle and liver for exercise situations where carbohydrate availability may be a challenge. Additionally, the capacity of caffeine to enhance fat utilization during exercise could be of interest for improving health outcomes as it may increase the rate of change in body composition in exercise programs. Maximal fat oxidation rate (MFO) during exercise is a remarkable physiological indicator associated with metabolic flexibility/body weight loss and endurance performance To date, it is unknown if caffeine increases MFO in the same proportion during morning and evening exercise trials in women. For this reason, the aim of the present study was to evaluate the influence of the time of the day on the effect of caffeine on MFO in women. We hypothesised that caffeine would increase MFO during morning and evening exercise and this effect would be of similar magnitude at both times of day.

Interventions

To evaluate the influence of the time of the day (i.e., morning vs evening) on the effect of caffeine on maximal fat oxidation in women.

Sponsors

Universidad de Granada
CollaboratorOTHER
Universidad Rey Juan Carlos
CollaboratorOTHER
Camilo Jose Cela University
CollaboratorOTHER
Universidad Francisco de Vitoria
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Intervention model description

Dietary Supplement: caffeine acute supplementation

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* To be non-smokers. * To have low caffeine intake (i.e., \< 50 mg of caffeine per day in the previous 2 months) * To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months. * To have a regular duration of their menstrual cycle for the previous 6 months. * To confirm no existence of any type of menstrual disorders such as dysmenorrhea, amenorrhea, or strong symptoms associated with pre-menstrual syndrome.

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
MFO2-monthsMaximal fat oxidation during exercise

Secondary

MeasureTime frameDescription
FATmax2-monthsThe intensity of exercise that elicits MFO
RPE2-monthsRate of percevied exertion during exercise
FAT AND CHO oxidation2-monthsFat and carbohydrates oxidation

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026