Helicobacter Pylori Infection
Conditions
Brief summary
To study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
Detailed description
o study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori. our study include 2 patient groups: 1. st group included 100 child diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment and vitamin D as an adjuvant therapy . 2. nd group will also diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment only. Helicobacter pylori treatment : 1. amoxcillin on 50 mg/kg/day for 2 weeks 2. clarithromycin 20mg/kg/day for 2 weeks 3. proton pump inhibitor 1mg/kg/day for 1month Vitamin d dose..1000unit /day for 1 month
Interventions
DRUGVitamin D3
Vitamin D3 ,1000 unit ,once daily, oral, for 1 month plus triple therapy
DRUGHelicobacter pylori triple therapy
Triple therapy which is: amoxcillin on 50 mg/kg/day for 2 weeks, Clarithromycin 20mg/kg/day for 2 weeks and proton pump inhibitor 3.ppi 1mg/kg/day for 1month
Sponsors
Ain Shams University
Minia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
To study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
\- Age:4-18 years children with symptomatic H pylori infection presenting with (epigastric pain, persistent vomiting and hematemesis)diagnosed by upper gastrodeudonoscopy , rapid urease test and histopathologic examination of gastric biopsies from antrum and body of the stomach.
Exclusion criteria
* Patient on vitamine D supplémentation * Patient who has defect in vitamin D metabolism (chronic renal and hepatic patients, malabsorption syndromes) * Patients who had received treatment of H.pylori previously .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children | Six month | eradication of h pylori in children |
Contacts
Primary ContactGihan M bebars, proffesor
Backup ContactAhmed M hamdy, proffesor
Outcome results
None listed