Creation of a Multicenter National Registry for Peripartum Cardiomyopathy.

Conditions

Peripartum Cardiomyopathy

Brief summary

Peripartum cardiomyopathy (PPCM) is a rare, severe and potentially life-threatening disorder of largely unknown etiology and pathophysiology, with unexplained geographical differences and heterogeneous presentation. Investigators hypothesize that a network-based multidisciplinary strategy integrating clinical and molecular phenotyping of PPCM patients might anticipate diagnosis, optimize treatments, and identify novel mechanisms to achieve the unmet goal of personalized medicine.

Detailed description

Specific aims of this study are: a) to create a multicenter pilot registry of PPCM in different areas in Italy to assess incidence and prevalence of this rare disease, associated comorbidities and risk factors. b) to deeply characterize identified PPCM patients through clinical, imaging, genetic, biochemical, and molecular phenotyping. c) to gain novel mechanistic information on PPCM by performing deep clinical and molecular phenotyping in available biobanks samples of patients with PPCM and healthy controls.

Federica Ilardi, Federica Carusone, Dario D’Alconzo, Rachele Manzo, Alessia Palmentieri et al. (28 authors)

Frontiers in Cardiovascular Medicine2026-08-26

10.3389/fcvm.2026.1860070

Abstract 4366557: Assessment of Myocardial Function Recovery in Peripartum Cardiomyopathy: Role of Global Longitudinal Strain and Myocardial Work

Federica Ilardi, Federica Carusone, Rachele Manzo, Cristina Battaglia, Alessia Palmentieri et al. (16 authors)

Circulation2025-11-03

10.1161/circ.152.suppl_3.4366557

Abstract 4366881: Clinical and Echocardiographic Correlates of Persistent Left Ventricle Dysfunction in Peripartum Cardiomyopathy: Insights from the Italian Multicentre Registry

Federica Ilardi, Rachele Manzo, Federica Carusone, Dario D’Alconzo, Alessia Palmentieri et al. (16 authors)

Circulation2025-11-03

10.1161/circ.152.suppl_3.4366881

Clinical presentation and echocardiographic characteristics of women with peripartum cardiomyopathy: Insights from the Italian Multicentre Registry.

Ilardi F, Manzo R, Peretto G, Lanni F, Peano V, Loffredo FS, Masarone D, Gerardi D, di Maio S, Bardi L, Licciardi M, Montali N, Pezzullo E, Di Lorenzo E, Stabile E, Battaglia C, Calanducci M, Bifulco G, Anastasia L, Carusone F, Cascone A, Di Santo M, Cavoretto PI, D'Alconzo D, Palmentieri A, Carotenuto M, Di Spiezio Sardo A, Ioele D, Paolillo R, Polese P, Saccone G, Esposito G, Chieffo A, Perrino C.

2025-09-041 citations

10.1016/j.ijcard.2025.133866

Interventions

DIAGNOSTIC_TESTMolecular and genetic screening

Molecular and genetic screening

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Development of HF signs or symptoms in the last month of pregnancy or within 5 months of delivery; * Left ventricle systolic dysfunction demonstrated by classical echocardiographic criteria (LVEF\< 45 %) in the last month of pregnancy or within 5 months of delivery.

Exclusion criteria

* Presence of any identifiable cause of HF; * Presence of recognizable heart disease before the last month of pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
Death or hospitalization due to heart failure	0-6 months	Death or hospitalization due to heart failure during the follow-up period
Development of significant cardiac arrhythmias	0-6 months	New onset sustained supraventricular or ventricular arrhythmias or conduction blocks during the follow-up period

Secondary

Measure	Time frame	Description
Left ventricular dysfunction	0-6 months	Left ventricular % ejection fraction during the follow-up period

Countries

Italy

Contacts

Primary ContactCinzia Perrino

perrino@unina.it+39 081 7462223

Outcome results

None listed