Opioid Use, Pain, Chronic, Pain, Postoperative, Quality of Life
Conditions
Brief summary
The aim of this study is to document the perioperative opioid use and its safety in the UK and countries in Europe and to describe its association with surgical complications, persistent pain and quality of life. In an international, prospective, observational cohort study, data about the perioperative pain management will be collected in all eligible hospitalised adult patients who undergo surgery in a designated study week in as many hospitals as possible in Europe. Baseline data will be collected, and participants followed up at one week, and at three and twelve months post-operatively. The primary outcome will be opioid use at three months after surgery. Secondary outcomes will include opioid use during the preoperative month (preoperative use), during surgery and up to one week after surgery (or discharge, whichever is earlier), and up to the end of the postoperative year. Additional secondary outcomes are the incidence of preoperative pain, persistent pain with/without the presence of neuropathic components, quality of life and surgical complications. The potential association between opioid use and pain outcomes will be investigated. This study could help to develop strategies to improve quality of care, through pain management, for patients undergoing surgery.
Detailed description
PANDOS is an international, prospective, observational cohort study. In a one week period (the designated study week), data will be collected in all eligible hospitalised adult patients who undergo surgery in as many hospitals as possible in the UK and Europe. Participants will be followed up for 12 months
Interventions
None listed
Sponsors
European Society of Anaesthesiology and Intensive Care
University of Aberdeen
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* hospitalised adult patients (18 years and older) undergoing any inpatient surgery (elective or emergency) during the designated study week where an anaesthetist is involved (general anaesthetic, sedation, local anaesthetic). Able to understand and has capacity to give written informed consent
Exclusion criteria
* American Society of Anaesthesiologists (ASA) grade V or VI * Refusal to participate. * Lack of comprehension of validated questionnaires or inability to complete the follow-up for any reason. * Lack of capacity to give written informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient reported Opioid use post surgery | 3 months | Patient reported use of opioids post surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient reported incidence of pain pre-op and post surgery using BPI-SF | From recruitment to 1 year post surgery | Patient reported incidence of pain pre-op and post surgery using BPI-SF |
| Patient reported incidence of pain pre-op and post surgery using DN2 | From recruitment to 1 year post surgery | Patient reported incidence of pain pre-op and post surgery using DN2 |
| Opioid use | From recruitment to 1 year post surgery | Patient reported use of opioids pre-op and opioids used during surgery and prescribed post surgery |
| Participant reported quality of life EQ5D-5L | From recruitment to 1 year post surgery | EQ5D-5L |
| Participant reported quality of life BPI-SF | From recruitment to 1 year post surgery | BPI-SF |
| Surgical complications | During surgery | Recording of surgical complications during surgery |
Countries
Croatia, United Kingdom
Contacts
Primary ContactPatrice Forget
Backup ContactHolly R Keir, PhD
Outcome results
None listed