Infection, Bloodstream
Conditions
Brief summary
An increase of healthcare-associated infections caused by multidrug- resistant organisms (MRDO) is currently observed. One of the main causes of the emergence of a MDRO infection is an overuse of antibiotics. Therefore, saving useless antibiotic treatment is currently a priority from a public health point of view. The evaluation of the risk of having a bloodstream infection will allow both activating faster treatment decisions (when the risk is significantly high) or to save useless resources in terms of diagnostic tests and treatments, also limiting the potential for side effects (when the risk is significantly low).
Interventions
The outcome of the study will be to implement Prediction Models to support clinicians for the assessment of risk of having a bloodstream infection.
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. adult patients hospitalized at the Gemelli Polyclinic Foundation 2. having at least one performed blood culture 3. starting an antibiotic therapy
Exclusion criteria
1. blood cultures with contaminants 2. \<18 years old 3. died after less than 48 hours from blood cultures positivity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of appropriate antibiotic therapy in patients with bloodstream infections | 24 months | 1\) number of patients with bloodstream infections with appropriate antibiotic therapy before and after the application of the predictive model Bacterium |
| Blood cultures | 24 months | number of blood cultures done before and after the application of the predictive model Bacterium |
Countries
Italy
Contacts
Primary Contactrita murri
Outcome results
None listed