The Predictive Value of Progesterone

The Predictive Value of the Progesterone Level on the Day of Embryo Transfer in Cryo Cycles

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05876234

Acronym

PFRET

Enrollment

3000

Registered

2023-05-25

Start date

2023-04-25

Completion date

2025-12-31

Last updated

2024-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility

Keywords

progesterone, embryo transfer

Brief summary

To evaluate a 5 ng/ml serum progesterone (P4) threshold policy for the addition of subcutaneous (SC) P4 in artificially prepared frozen embryo transfer cycles treated with vaginal P4. We assess whether the addition of SC P4 rescues cycles with serum P4 \<5 ng/ml and we study the impact of not supplementing cycles with serum P4 \>5 ng/ml by comparing them with serum P4 cycles above the conventionally proposed cut-off of 10 ng/ml.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 47 Years

Healthy volunteers

Inclusion criteria

* Embryo transfer between March 1st 2021 and March 31st 2023 * Determination of progesterone on the day of embryo transfer

Design outcomes

Primary

Measure	Time frame	Description
Ongoing pregnancy rate	11 to 13 weeks after last menstruation	Fetal heart beat at ultrasound

Secondary

Measure	Time frame	Description
Clinical pregnancy rate	6 to 8 weeks after last menstruation	Ultrasound visualisation of the gestational sac

Countries

Belgium

Outcome results