Endometrial Cancer
Conditions
Keywords
radiation therapy, hypofractionation
Brief summary
To investigate the non-inferiority of disease-free survival in women who received hypofractionated intensity-modulated whole pelvic radiation therapy (2.5 Gy x 16 fractions) after curative surgery for stage III endometrial cancer.
Interventions
RADIATIONPOHIM_EM
hypofractionated intensity-modulated radiation therapy (2.5 Gy/fraction, 16 fractions)
Sponsors
Samsung Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
hypofractionated IMRT (2.5 Gy x 16 fractions)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* histologically confirmed endometrioid type endometrial cancer * completion of hysterectomy and surgical staging * pathologically confirmed FIGO stage III * ECOG performance status 0 or 1 * adjuvant chemotherapy was done or planned
Exclusion criteria
* presence of distant metastasis * previous history of pelvic radiotherapy * severe and unstable medical condition * previous history of other carcinoma except for thyroid cancer, skin cancer, and endometrial cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 5-year disease-free survival rate | 5 years | disease-free survival rate after the time of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| acute toxicities | 3 months | acute toxicities within 3 months according to CTCAE v5.0 |
| late toxicities | 5 years | late toxicities according to CTCAE v5.0 |
Countries
South Korea
Contacts
Primary ContactWon Park
Backup ContactWon Kyung Cho
Outcome results
None listed