Tobacco-Related Carcinoma
Conditions
Brief summary
This clinical trial tests the effect of tobacco flavor and liquid composition on the way a person puffs on a vape (topography). In general, tobacco products are designed with sensory factors in mind, such as flavor, to increase the appeal. Flavors and the composition of nicotine, either made in a lab (synthetic) or from tobacco, may create positive sensory effects, such as look, feel and taste, and influence smoking behavior and willingness to try different types of cigarettes. Understanding how nicotine vaping products are used is important in assessing individual and population level health risks. Vape flavors and synthetic nicotine may be related to harmful effects on health from vaping and may impact the appeal, risk beliefs and vaping topography.
Detailed description
PRIMARY OBJECTIVE: * Examine the influence of tobacco flavoring composition on vaping topography. * Examine the influence of synthetic versus (vs.) tobacco derived nicotine on vaping topography. SECONDARY OBJECTIVE: * Examine the influence of tobacco flavoring composition on vaping topography. * Examine the influence of synthetic versus (vs.) tobacco derived nicotine on vaping topography. OUTLINE: The order of directed and ad libitum bouts are randomized within participants at each session. SESSION 1: Participants puff their own brand liquid on study. SESSIONS 2-5: Participants puff 1 of 4 randomly assigned tobacco flavor formulations at each visit on study. SESSIONS 6-7: Participants puff 1 of 2 randomly assigned nicotine formulations at each visit on study. Participants also undergo collection of saliva samples and optionally undergo collection of oral cell and oral rinse samples throughout study.
Interventions
OTHERVaping
Undergo vape puffing regimen
PROCEDUREBiospecimen Collection
Undergo collection of saliva samples and oral cell samples
OTHERQuestionnaire Administration
Administer Quesitonnaire
Sponsors
National Cancer Institute (NCI)
Roswell Park Cancer Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Current daily vapers of products containing nicotine * No daily concurrent use of other tobacco products * Self-reported general good health * Women of child bearing potential must be willing to provide a urine sample and test negative prior to receiving any study-related products/procedures * Ability to speak, read, and write in English * Participant must understand the investigational nature of this study and sign an independent ethics committee/institutional review board approved written informed consent form prior to receiving any study related procedure
Exclusion criteria
* Allergies - active untreated seasonal allergies that would interfere with smell or taste procedures * Self-reported taste or smell deficits * Pregnant or nursing female participants * Medications known to interfere with taste/smell (i.e., certain nasal sprays, nasal antihistamines, decongestants, antibiotics, medications containing zinc) * Unwilling to use open system vaping device in laboratory setting * Positive diagnosis of human coronavirus 2019 infection (COVID-19) within 10 days prior to start of study intervention * Unwilling or unable to follow protocol requirements * Any condition which in the investigator's opinion deems the participant an unsuitable candidate to receive the study intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Puff Topography: Puff Count | Single Session, Approximately 2 hours in duration | Measure of vaping topography counting total number of puffs. |
| Puff Topography: Puff Duration (in Seconds) | Single Session, Approximately 2 hours in duration | Measure of vaping topography counting duration of puffs in seconds. |
| Puff Topography: Inter Puff Interval (IPI) | Single Session, Approximately 2 hours in duration | Measure of vaping topography counting the interval between puffs in seconds. |
| Puff Topography: Puff Volume | Single Session, Approximately 2 hours in duration | Measure of vaping topography measuring the volume per puff in ml. |
| Puff Topography: Flow Rate | Single Session, Approximately 2 hours in duration | Measure of vaping topography measuring the rate of flow per puff in milliliters per second. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Questionnaires of Product Evaluation | Single Session, Approximately 2 hours in duration | Will be assessed by Duke Sensory Scale |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Vaping - Description The order of directed and ad libitum bouts are randomized within participants at each session.
SESSION 1: Participants puff their own brand liquid on study.
SESSIONS 2-5: Participants puff 1 of 4 randomly assigned tobacco flavor formulations at each visit on study.
SESSIONS 6-7: Participants puff 1 of 2 randomly assigned nicotine formulations at each visit on study.
Participants also undergo collection of saliva samples and optionally undergo collection of oral cell and oral rinse samples throughout study.
Vaping: Undergo vape puffing regimen
Biospecimen Collection: Undergo collection of saliva samples and oral cell samples
Questionnaire Administration: Administer Quesitonnaire | 18 |
| Total | 18 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Sessions 2-5: Tobacco Flavors | Lost to Follow-up | 1 |
Baseline characteristics
| Characteristic | Vaping - |
|---|---|
| Age, Continuous | 35.8 years STANDARD_DEVIATION 10.76 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 17 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 3 Participants |
| Race (NIH/OMB) Black or African American | 5 Participants |
| Race (NIH/OMB) More than one race | 1 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 2 Participants |
| Race (NIH/OMB) White | 7 Participants |
| Region of Enrollment United States | 18 participants |
| Sex: Female, Male Female | 11 Participants |
| Sex: Female, Male Male | 7 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk | EG006 affected / at risk | EG007 affected / at risk | EG008 affected / at risk | EG009 affected / at risk | EG010 affected / at risk | EG011 affected / at risk | EG012 affected / at risk | EG013 affected / at risk |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 18 | 0 / 18 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 |
| other Total, other adverse events | 0 / 18 | 0 / 18 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 |
| serious Total, serious adverse events | 0 / 18 | 0 / 18 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 | 0 / 17 |
Outcome results
Primary
Puff Topography: Flow Rate
Measure of vaping topography measuring the rate of flow per puff in milliliters per second.
Time frame: Single Session, Approximately 2 hours in duration
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Puff Topography: Flow Rate | 28.4 ml per second | Standard Error 3.4 |
| Session 1: Own Brand Puff Count Directed | Puff Topography: Flow Rate | 28.7 ml per second | Standard Error 3.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 28.2 ml per second | Standard Error 2.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Puff Topography: Flow Rate | 25.5 ml per second | Standard Error 2.7 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 29.3 ml per second | Standard Error 2.4 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Puff Topography: Flow Rate | 24.8 ml per second | Standard Error 2.6 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 27.8 ml per second | Standard Error 2.9 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Puff Topography: Flow Rate | 25.2 ml per second | Standard Error 2.8 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 27.8 ml per second | Standard Error 2.4 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Puff Topography: Flow Rate | 24.2 ml per second | Standard Error 1.9 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 33.7 ml per second | Standard Error 2.1 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Puff Topography: Flow Rate | 31.4 ml per second | Standard Error 2.1 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Puff Topography: Flow Rate | 33.9 ml per second | Standard Error 2.6 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Puff Topography: Flow Rate | 30.0 ml per second | Standard Error 2.32 |
Primary
Puff Topography: Inter Puff Interval (IPI)
Measure of vaping topography counting the interval between puffs in seconds.
Time frame: Single Session, Approximately 2 hours in duration
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 82.2 Mean number of seconds between puffs | Standard Error 14 |
| Session 1: Own Brand Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 55.2 Mean number of seconds between puffs | Standard Error 6.1 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 61.4 Mean number of seconds between puffs | Standard Error 10.7 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 58.0 Mean number of seconds between puffs | Standard Error 4.2 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 71.6 Mean number of seconds between puffs | Standard Error 10.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 54.2 Mean number of seconds between puffs | Standard Error 3.6 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 71.6 Mean number of seconds between puffs | Standard Error 8.7 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 56.7 Mean number of seconds between puffs | Standard Error 4 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 55.1 Mean number of seconds between puffs | Standard Error 8.1 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 60.6 Mean number of seconds between puffs | Standard Error 5.4 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 84.6 Mean number of seconds between puffs | Standard Error 12 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 59.3 Mean number of seconds between puffs | Standard Error 4.1 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Puff Topography: Inter Puff Interval (IPI) | 78.7 Mean number of seconds between puffs | Standard Error 11 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Puff Topography: Inter Puff Interval (IPI) | 56.6 Mean number of seconds between puffs | Standard Error 3.5 |
Primary
Puff Topography: Puff Count
Measure of vaping topography counting total number of puffs.
Time frame: Single Session, Approximately 2 hours in duration
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Puff Topography: Puff Count | 13.9 Number of Puffs | Standard Error 2.3 |
| Session 1: Own Brand Puff Count Directed | Puff Topography: Puff Count | 6.4 Number of Puffs | Standard Error 0.8 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 13.2 Number of Puffs | Standard Error 2.2 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Puff Topography: Puff Count | 5.8 Number of Puffs | Standard Error 0.8 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 15.4 Number of Puffs | Standard Error 3.1 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Puff Topography: Puff Count | 5.9 Number of Puffs | Standard Error 0.9 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 13.2 Number of Puffs | Standard Error 2.2 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Puff Topography: Puff Count | 5.8 Number of Puffs | Standard Error 0.9 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 13.0 Number of Puffs | Standard Error 2.2 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Puff Topography: Puff Count | 6.3 Number of Puffs | Standard Error 1.2 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 14.3 Number of Puffs | Standard Error 2.4 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Puff Topography: Puff Count | 7.1 Number of Puffs | Standard Error 0.9 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Puff Topography: Puff Count | 13.4 Number of Puffs | Standard Error 1.8 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Puff Topography: Puff Count | 7.0 Number of Puffs | Standard Error 0.9 |
Primary
Puff Topography: Puff Duration (in Seconds)
Measure of vaping topography counting duration of puffs in seconds.
Time frame: Single Session, Approximately 2 hours in duration
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.2 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Session 1: Own Brand Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 3.5 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.3 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 3.1 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.5 Mean Duration of Puffs (in seconds) | Standard Error 0.4 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 3.0 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.3 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 3.2 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.1 Mean Duration of Puffs (in seconds) | Standard Error 0.2 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 2.9 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.4 Mean Duration of Puffs (in seconds) | Standard Error 0.4 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 3.0 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Puff Topography: Puff Duration (in Seconds) | 2.2 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Puff Topography: Puff Duration (in Seconds) | 2.9 Mean Duration of Puffs (in seconds) | Standard Error 0.3 |
Primary
Puff Topography: Puff Volume
Measure of vaping topography measuring the volume per puff in ml.
Time frame: Single Session, Approximately 2 hours in duration
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Puff Topography: Puff Volume | 63.5 Volume per puff (ml) | Standard Error 13.2 |
| Session 1: Own Brand Puff Count Directed | Puff Topography: Puff Volume | 102.2 Volume per puff (ml) | Standard Error 16.1 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 66.2 Volume per puff (ml) | Standard Error 11.4 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Puff Topography: Puff Volume | 81.4 Volume per puff (ml) | Standard Error 14.7 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 83.6 Volume per puff (ml) | Standard Error 17.2 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Puff Topography: Puff Volume | 103.1 Volume per puff (ml) | Standard Error 18.6 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 63.9 Volume per puff (ml) | Standard Error 8.1 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Puff Topography: Puff Volume | 88.3 Volume per puff (ml) | Standard Error 13.5 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 57.5 Volume per puff (ml) | Standard Error 6.5 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Puff Topography: Puff Volume | 74.9 Volume per puff (ml) | Standard Error 10.61 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 86.7 Volume per puff (ml) | Standard Error 14.9 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Puff Topography: Puff Volume | 96.3 Volume per puff (ml) | Standard Error 13.5 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Puff Topography: Puff Volume | 76.9 Volume per puff (ml) | Standard Error 9.8 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Puff Topography: Puff Volume | 92.0 Volume per puff (ml) | Standard Error 15.2 |
Secondary
Subjective Questionnaires of Product Evaluation
Will be assessed by Duke Sensory Scale
Time frame: Single Session, Approximately 2 hours in duration
Population: Mean sensory and subjective effects scores by bout type and flavor condition, Sub-Study A.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Session 1: Own Brand Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 5.3 units on a scale | Standard Error 0.4 |
| Session 1: Own Brand Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 45.2 units on a scale | Standard Error 12 |
| Session 1: Own Brand Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 4.8 units on a scale | Standard Error 0.4 |
| Session 1: Own Brand Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 72.3 units on a scale | Standard Error 7.3 |
| Session 1: Own Brand Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 50.2 units on a scale | Standard Error 11.4 |
| Session 1: Own Brand Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.7 units on a scale | Standard Error 0.6 |
| Session 1: Own Brand Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 77.0 units on a scale | Standard Error 5.7 |
| Session 1: Own Brand Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 34.8 units on a scale | Standard Error 8.6 |
| Session 1: Own Brand Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 33.2 units on a scale | Standard Error 15.9 |
| Session 1: Own Brand Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 4.2 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | -3.2 units on a scale | Standard Error 15.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 69.7 units on a scale | Standard Error 4.4 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 34.2 units on a scale | Standard Error 6.6 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 3.9 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 2.8 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 2.6 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | -32.6 units on a scale | Standard Error 15.5 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.4 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 64.1 units on a scale | Standard Error 5.6 |
| Sessions 2-5: Cowboy Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 44.4 units on a scale | Standard Error 4.9 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.0 units on a scale | Standard Error 0.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 61.1 units on a scale | Standard Error 6.5 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 3.9 units on a scale | Standard Error 13.1 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 38.9 units on a scale | Standard Error 6.5 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 2.7 units on a scale | Standard Error 0.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | -2.5 units on a scale | Standard Error 13.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 44.7 units on a scale | Standard Error 7.8 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.2 units on a scale | Standard Error 0.3 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 71.6 units on a scale | Standard Error 4.5 |
| Sessions 2-5: RY4 Double Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.0 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 72.9 units on a scale | Standard Error 4.7 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 25.4 units on a scale | Standard Error 5.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.1 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 16.4 units on a scale | Standard Error 15.2 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.3 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 75.5 units on a scale | Standard Error 4.2 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 37.7 units on a scale | Standard Error 15.7 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.1 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 45.1 units on a scale | Standard Error 6.3 |
| Sessions 2-5: Unflavored Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.4 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 68.8 units on a scale | Standard Error 5 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.1 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 36.2 units on a scale | Standard Error 5.6 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.5 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | -2.0 units on a scale | Standard Error 14.8 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.5 units on a scale | Standard Error 0.3 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 22.4 units on a scale | Standard Error 16.2 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 2.9 units on a scale | Standard Error 0.4 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 72.5 units on a scale | Standard Error 4.7 |
| Sessions 2-5: Red Oak Vaping Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 33.4 units on a scale | Standard Error 5.1 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 26.2 units on a scale | Standard Error 11.6 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 27.8 units on a scale | Standard Error 5.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 71.9 units on a scale | Standard Error 5 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.4 units on a scale | Standard Error 0.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.8 units on a scale | Standard Error 0.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.4 units on a scale | Standard Error 0.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.7 units on a scale | Standard Error 0.4 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 29.8 units on a scale | Standard Error 5.7 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 74.2 units on a scale | Standard Error 5.3 |
| Session 6-7: Synthetic Nicotine Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 21.2 units on a scale | Standard Error 12.9 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 1.2 units on a scale | Standard Error 11.6 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.1 units on a scale | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.4 units on a scale | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 21.0 units on a scale | Standard Error 5.2 |
| Session 6-7: Tobacco Derived Liquid Puff Count Ad Lib | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 66.2 units on a scale | Standard Error 6.6 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluaton Sore: Relief (1 not at all - 7 extremely) | 4.6 units on a scale | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Draw (0 less draw - 100 more draw) | 74.1 units on a scale | Standard Error 5.2 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Pleasantness (-100 less pleasant - +100 more pleasant) | 7.5 units on a scale | Standard Error 14.8 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Product Evaluation Score: Satisfaction (1 not at all - 7 extremely) | 3.2 units on a scale | Standard Error 0.3 |
| Session 6-7: Tobacco Derived Liquid Puff Count Directed | Subjective Questionnaires of Product Evaluation | Tingling Sensation (0 less tingling sensation - 100 more tingling sensation) | 29.0 units on a scale | Standard Error 6.1 |