Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor

Evaluation of Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor for Extraction of Maxillary Teeth in Diabetic Patients Double Blind Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05875519

Enrollment

Registered

2023-05-25

Start date

2023-05-20

Completion date

2023-11-30

Last updated

2024-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Local, Diabetes

Brief summary

Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients

Interventions

DRUGLocal anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)

Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Inclusion criteria patients over 20 years and under 60 years of age * DM controlled by medication * Requiring a tooth extraction in the maxilla, with an indication of the intra-alveolar technique for periodontal reasons. * Only participants that are willing to control and record blood glucose level throughout the study period.

Exclusion criteria

* Patients with any significant medical condition (besides DM) * Alcoholic individuals * Patients on drugs that affect the central nervous systems * Patients who reported the use of drugs that might interfere with pain sensitivity * Pregnant and lactating women * Patients with hypersensitivity to local anesthetics or non-steroidal anti-inflammatory drugs (NSAIDs).

Design outcomes

Primary

Measure	Time frame
Glycemic level recorded before local anesthesia administration and 30 minutes following local anesthesia injection using glucometer	30 minutes

Secondary

Measure	Time frame	Description
Healing score of the extraction socket	21 days	4 = Necrotic Tissue (Eschar): black, brown, or tan tissue that adheres firmly to the wound bed 3 = Slough: yellow or white tissue that adheres to the wound bed 2 = Granulation Tissue: pink or beefy red tissue with a shiny, moist, granular appearance. 1 = Epithelial Tissue: for superficial ulcers, new pink or shiny tissue that grows in from the edges or as islands on the wound surface. 0 = Closed/Resurfaced: the wound is completely covered with epithelium.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026