Periodontitis
Conditions
Keywords
mouthwash, periodontitis, resveratrol
Brief summary
To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis
Detailed description
* Measuring and comparing the efficacy of RV mouth wash in comparison with CHX and placebo mouth wash in improving the clinical periodontal parameters; * Measuring the salivary cytokines (IL-6) before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. * Measuring the salivary RANKL before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. * Correlate the salivary cytokines IL-6 and salivary RANKL with clinical periodontal parameter and with each other. * Evaluate the intervention by using Visual analog scale (VAS)- score-based questionnaire will be filled out by each participant at the end of the trial.
Interventions
OTHERresveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
OTHERchlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
OTHERplacebo mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
Sponsors
University of Baghdad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
the supervisor will place the mouthwash in dark bottle with number so neither the examiner nor the patient will know the type of the mouthwash
Intervention model description
the study include three groups. one of them is the study group in which the patient will use resveratrol mouthwash as adjunct to scaling, the second group use chlorhexidine mouthwas as adjunct to scaling while the third group will use a placebo. all the participants and the examiner are blinded regarding the type of the mouthwash they will be using
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
\- The inclusion criteria: 1. Participants need to be systemically healthy with age \> 18 years old. 2. Not taking antibiotic and anti-inflammatory drugs in the last three months. 3. At least 20 teeth should be present 4. Should have unstable periodontitis (PPD ≥ 5 or BOP at 4mm pocket) The
Exclusion criteria
1. Patients wearing fixed prosthesis (crowns, bridges or orthodontic appliances) 2. Those with chronic disease, immunocompromised patients, pregnant, on contraceptives or lactating women. 3. Those currently using any mouthwash. 4. Those on antibiotic therapy and anti-inflammatory medications during the study and in the last 3 months before the study. 5. Those having a history of hypersensitivity to any product used in the present study. 6. Those who are smokers or alcoholics. 7. Those who refuse to participate in the trial. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bleeding on probing | at1 month from the baseline | bleeding on probing |
Countries
Iraq
Contacts
Primary ContactHadeel MA [hakram], master
Outcome results
None listed