Blood Pressure
Conditions
Keywords
self-measured morning home systolic blood pressure (AM H-SBP)
Brief summary
Fine particulate matter \<2.5 µm (PM2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (CVD). While several mechanisms are responsible, PM2.5-induced elevations in blood pressure (BP) may be relevant. Indoor portable air cleaners (PACs) are a novel approach to reduce exposure to PM2.5 and potentially lower blood pressure. The current study is being conducted to provide evidence that PACs reduce PM2.5 exposure and lower systolic blood pressure (SBP) in key patient populations.
Interventions
DEVICEActive PAC
The active PAC will contain HEPA filters inside the device.
DEVICESham PAC
The sham PAC will contain no HEPA filters inside the device.
Sponsors
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* self-reported nonsmokers living in a nonsmoking household. * adults living with hypertension (HTN) from NYC public housing.
Exclusion criteria
* History of major known arrhythmias (e.g. atrial flutter or fibrillation, ventricular tachycardia). * Screening systolic BP ≥160 mm Hg or diastolic BP ≥100 mm Hg (i.e. severe hypertension by the 2017 ACC/AHA BP guideline). * A change in drug regimen in the prior 2 weeks or a planned change in drug regimen during the first 30 days for those taking antihypertensive medication. * Current smoking or living with an active smoker who smokes indoors * Planned travel out of NYC for ≥2 weeks in next 6 months * Incarcerated * Pregnant * Unable/unwilling to consent * Established cardiovascular disease * End-stage renal disease (chronic kidney disease stage IV or on dialysis) * Barrier to technology use (e.g., visual or hearing impairment) * Lung disease requiring oxygen * Cancer receiving treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 30 Days | Up to Day 30 | Participants measure HBP every day between 6-9 am. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 90 Days | Up to Day 90 | Participants measure HBP every day between 6-9 am. |
| Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 180 Days | Up to Day 180 | Participants measure HBP every day between 6-9 am. |
Countries
United States
Contacts
CONTACTJonathan Newman
CONTACTElle Anastasiou Pesante
PRINCIPAL_INVESTIGATORJonathan Newman
NYU Langone Health
Outcome results
None listed