Arrhythmias, Cardiac, Atrial Fibrillation, Cardiovascular Diseases, Heart Diseases, Pathologic Processes
Conditions
Brief summary
Single center prospective study to analyze the impact of diabetes mellitus on patients' outcome following radiofrequency-guided catheter ablation for atrial fibrillation.
Detailed description
A total number of 50 patients with diabetes mellitus will undergo radiofrequency-guided catheter ablation for atrial fibrillation. Pre-procedural cardiac MRI will be performed with late-gadolinium enhancement to visualize the individual amount and distribution of fibrosis in the right and left atrium. The relationship between diabetes mellitus and individual atrial arrhythmia substrates as well as patients' outcome following catheter ablation will be analyzed.
Interventions
None listed
Sponsors
Heart and Diabetes Center North-Rhine Westfalia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing their 1st radiofrequency-guided catheter ablation for atrial fibrillation * Diabetes mellitus * Able to understand and willing to sign the Informed Consent Form. * Age ≥18 years.
Exclusion criteria
* Contraindication for DE-MRI with a full dose of gadolinium-based contrast agent. * Previous left atrial ablation or surgical procedure * Women currently pregnant, breastfeeding, or of childbearing age not currently taking or not willing to use a reliable form of contraception * Mental or physical inability to take part in the study * Morbid obesity (BMI \> 35), or inability to be placed in MRI due to body mass.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| atrial fibrillation recurrence | 12 months | atrial fibrillation recurrence following catheter ablation |
Countries
Germany
Contacts
Primary ContactDenise Guckel, MD
Backup ContactAstrid Kleemeyer
Outcome results
None listed