Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS

Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05873647

Enrollment

Registered

2023-05-24

Start date

2023-05-01

Completion date

2025-05-01

Last updated

2023-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness

Brief summary

Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO reactivity and the physiological mechanism underlying changes in oxygenation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients aged ≥ 18 years; 2. Patients are intubated and mechanically ventilated.

Exclusion criteria

1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc; 2. With a history of cerebral hemorrhage in the past half year, as well as bleeding in any site of the body; 3. Pneumothorax; 4. Medium or massive pleural effusion; 5. Refractory shock; 6. Pregnant 7. With chronic kidney disease 8. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output; 9. Failure to sign informed consent

Design outcomes

Primary

Measure	Time frame	Description
Lung ventilation/perfusion ration	3 hours	Lung ventilation/perfusion ration after iNO assessed by EIT

Secondary

Measure	Time frame	Description
Shunting	30minutes and 3 hours	Lung shunting% after iNO assessed by EIT
Dead space	30minutes and 3 hours	Lung dead space after iNO assessed by EIT
Oxygenation index	30minutes and 3 hours	Oxygenation index= arterial partial pressure of oxygen/fraction of inspired oxygen
Lung perfusion distribution	30minutes and 3 hours	Lung ventilation/perfusion ration after iNO assessed by EIT
Static respiratory compliance (Crs)	30minutes and 3 hours	Crs=tidal volume/driving pressure
Cardiac output	30minutes and 3 hours	Cardiac output assessed by echocardiography
Right ventricular function	30minutes and 3 hours	Right ventricular function assessed by echocardiography
Arterial partial pressure of carbon dioxide (PaCO2)	30minutes and 3 hours	PaCO2 is one of the key indicators of pulmonary ventilation which can be obtained from arterial blood gas analysis.

Countries

China

Contacts

Primary ContactXiaojing Zou, prof.

249126734@qq.com+862785351606

Outcome results