Oxidative Stress
Conditions
Brief summary
This study investigated the effects of time-of-day of grape consumption on high-fat meal-induced oxidative stress.
Detailed description
Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 x 2 factorial randomized, controlled design wherein healthy men and women (n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1-6
Interventions
OTHERGrape
Reconstituted whole grape powder
Sponsors
Idaho State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Age 18-50 y
Exclusion criteria
* Employed in shift or night work * Extreme early or late chronotype * Presence of acute infection or chronic inflammatory disease * Smoking * Heavy aerobic exerciser * Greater than moderate alcohol intake * Pregnancy or lactation * Use of non-steroidal anti-inflammatory medications or antioxidant dietary supplements.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine F2-isoprostane | baseline | Oxidative stress marker |
Countries
United States
Outcome results
None listed